Mortality in COVID-19 disease patients: Correlating the association of major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variants

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Eric de SousaM. Maeurer

Abstract

Genetic factors such as the HLA type of patients may play a role in regard to disease severity and clinical outcome of patients with COVID-19. Taking the data deposited in the GISAID database, we made predictions using the IEDB analysis resource (TepiTool) to gauge how variants in the SARS-CoV-2 genome may change peptide binding to the most frequent MHC-class I and -II alleles in Africa, Asia and Europe. We caracterized how a single mutation in the wildtype sequence of of SARS-CoV-2 could influence the peptide binding of SARS-CoV-2 variants to MHC class II, but not to MHC class I alleles. Assuming the ORF8 (L84S) mutation is biologically significant, selective pressure from MHC class II alleles may select for viral varients and subsequently shape the quality and quantity of cellular immune responses aginast SARS-CoV-2. MHC 4-digit typing along with viral sequence analysis should be considered in studies examining clinical outcomes in patients with COVID-19.

Citations

Dec 29, 2020·Proceedings of the National Academy of Sciences of the United States of America·Thomas G FlowerJames H Hurley
Feb 13, 2021·AIMS Public Health·Srikanth UmakanthanMaryann Bukelo
Feb 26, 2021·Current Opinion in Pulmonary Medicine·Markus MaeurerAlimuddin Zumla
Apr 9, 2021·Journal of Medical Virology·Fatmah M A NaemiAshwaq Al-Nazawi
Apr 20, 2021·Frontiers in Immunology·Ingrid Fricke-Galindo, Ramcés Falfán-Valencia
May 6, 2021·Cell Transplantation·Chih-Hung YeShu-Han Yu
Jul 30, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Elisabeth PaulMartin Zizi
Aug 3, 2021·HLA : Immune Response Genetics·Emily SchindlerChang Liu
Sep 24, 2021·Frontiers in Genetics·Antonio ValcarcelJosé Díaz
Oct 5, 2021·Frontiers in Molecular Biosciences·Nico GerstnerHans-Peter Lenhof

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