Mortality in dialysis patients with cinacalcet use: A large observational registry study

European Journal of Internal Medicine
Claudia FriedlAlexander R Rosenkranz

Abstract

Secondary hyperparathyroidism (sHPT) is associated with higher mortality in dialysis patients. The calcimimetic cinacalcet reduces intact parathyroid hormone (iPTH) in dialysis patients. The randomized controlled EVOLVE trial failed to unequivocally prove survival advantage of cinacalcet in dialysis patients. However, recent post hoc analyses suggested a benefit in subgroups of dialysis patients. Large observational cohort studies may represent an option to better determine such subgroups. Data from the nationwide Austrian registry of dialysis patients between January 2004 and December 2009 were analyzed with follow-up until December 2010. All-cause and cardiovascular mortality analyses were performed using the Kaplan-Meier and Cox proportional hazards regression. To reduce confounding effects a propensity score (PS) based method (matching by stratification) was used for group comparison. The cohort included 7983 dialysis patients, 1572 (19.7%) were prescribed cinacalcet. During a median follow-up of 2.7years, 3574 (44.8%) patients died, including 1342 (16.8%) deaths from cardiovascular causes. Survival analyses in the PS-matched study population (n=6109) showed lower all-cause mortality for cinacalcet-treated as compared to un...Continue Reading

Citations

May 6, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Bradley A WaradyJustine Bacchetta
Mar 14, 2018·International Urology and Nephrology·M Rroji, G Spasovski
Oct 10, 2018·Nephrology·Yi-Chou HouKuo-Cheng Lu
Oct 7, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andras T DeakAlexander R Rosenkranz

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