Mortality in Patients with Endogenous Cushing's Syndrome

Endocrinology and Metabolism Clinics of North America
Pedram JavanmardEliza B Geer

Abstract

Cushing's syndrome is associated with increased morbidity and mortality. Cardiovascular events, sepsis, and thromboembolism are the leading causes of mortality. Patient's with Cushing's due to a pituitary adenoma and those with Cushing's due to benign adrenal adenoma have relatively good survival outcomes often mirroring that of the general population. Persistent or recurrent disease is associated with high mortality risk. Ectopic Cushing's syndrome and Cushing's due to adrenocortical carcinoma confer the highest mortality risk among Cushing's etiologies. Prompt diagnosis and treatment, and specific monitoring for and treatment of associated comorbidities are essential to decrease the burden of mortality from Cushing's.

Citations

Nov 16, 2019·Journal of Clinical Medicine·Hiroshi Nishioka, Shozo Yamada
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Oct 31, 2019·The Journal of Clinical Endocrinology and Metabolism·German RubinsteinMartin Reincke
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Dec 4, 2019·Frontiers in Endocrinology·Leah T BraunMartin Reincke
Jul 6, 2019·Pituitary·Ingrid Quevedo WanichiMaria Candida Barisson Villares Fragoso
Feb 1, 2021·The Journal of Clinical Endocrinology and Metabolism·Marie Helene Schernthaner-ReiterGreisa Vila
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