Mortality in patients with psychogenic nonepileptic seizures.

Neurology
Russell NightscalesTerence J O'Brien

Abstract

To investigate the hypothesis that patients diagnosed with psychogenic nonepileptic seizures (PNES) on video-EEG monitoring (VEM) have increased mortality by comparison to the general population. This retrospective cohort study included patients evaluated in VEM units of 3 tertiary hospitals in Melbourne, Australia, between January 1, 1995, and December 31, 2015. Diagnosis was based on consensus opinion of experienced epileptologists and neuropsychiatrists at each hospital. Mortality was determined in patients diagnosed with PNES, epilepsy, or both conditions by linkage to the Australian National Death Index. Lifetime history of psychiatric disorders in PNES was determined from formal neuropsychiatric reports. A total of 5,508 patients underwent VEM. A total of 674 (12.2%) were diagnosed with PNES, 3064 (55.6%) with epilepsy, 175 (3.2%) with both conditions, and 1,595 (29.0%) received other diagnoses or had no diagnosis made. The standardized mortality ratio (SMR) of patients diagnosed with PNES was 2.5 (95% confidence interval [CI] 2.0-3.3). Those younger than 30 had an 8-fold higher risk of death (95% CI 3.4-19.8). Direct comparison revealed no significant difference in mortality rate between diagnostic groups. Among deaths i...Continue Reading

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Citations

Jul 22, 2020·Neurology·Maria Jose Bruzzone Giraldez, W Curt LaFrance
Dec 7, 2020·Pharmacology Research & Perspectives·Benjamin StewartVikas Kotagal
Sep 17, 2020·Neurology·Emma FosterZanfina Ademi
Dec 6, 2020·Epilepsy & Behavior : E&B·Daniela Huepe-ArtigasRichard A A Kanaan
Feb 16, 2021·Epilepsia·Jenna HarowitzOrrin Devinsky
Feb 19, 2021·Seizure : the Journal of the British Epilepsy Association·Wesley T KerrJohn M Stern
Apr 27, 2021·Neurologic Clinics·Pouya Alexander AmeliCarolina B Maciel
May 5, 2021·Epilepsy & Behavior : E&B·Divyani Garg, Achal K Srivastava
May 25, 2021·Epilepsy Currents·M Scott Perry, Christos Papadelis
May 25, 2021·Epilepsy Currents·Adriana C Bermeo-Ovalle
Jul 20, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sándor BeniczkyEugen Trinka
Aug 8, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Johannes JungilligensStoyan Popkirov
Sep 23, 2021·Journal of Neurology·Andrew J DuncanUdaya Seneviratne
Nov 17, 2021·The Neurodiagnostic Journal·Roohi KatyalTammam Dayyoub

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