Mortality in people with psychotic disorders in Finland: A population-based 13-year follow-up study

Schizophrenia Research
Jaakko KeinänenJaana Suvisaari

Abstract

We conducted a population based study aiming at finding predictors of mortality in psychotic disorders and evaluating the extent to which sociodemographic, lifestyle and health-related factors explain the excess mortality. In a nationally representative sample of Finns aged 30-70years (n=5642), psychotic disorders were diagnosed using structured interviews and medical records in 2000-2001. Information on mortality and causes of death was obtained of those who died by the end of year 2013. Cox proportional hazards models were used to investigate the mortality risk. No people with affective psychoses (n=36) died during the follow-up, thus the analysis was restricted to non-affective psychotic disorders (NAP) (n=106). Adjusting for age and sex, NAP was statistically significantly associated with all-cause mortality (hazard ratio (HR) 2.99, 95% CI 2.03-4.41) and natural-cause mortality (HR 2.81, 95% CI 1.85-4.28). After adjusting for sociodemographic factors, health status, inflammation and smoking, the HR dropped to 2.11 (95% CI 1.10-4.05) for all-cause and to 1.98 (95% CI 0.94-4.16) for natural-cause mortality. Within the NAP group, antipsychotic use at baseline was associated with reduced HR for natural-cause mortality (HR 0.25,...Continue Reading

Citations

May 31, 2019·The Psychiatric Quarterly·Mary V Seeman
Jun 24, 2017·Schizophrenia Bulletin·Michael F GreenJonathan K Wynn
Jul 24, 2020·Current Opinion in Supportive and Palliative Care·Guy PeryerMorag Farquhar
Nov 30, 2018·Frontiers in Psychiatry·Jaana SuvisaariTuukka T Raij
May 11, 2019·Social Psychiatry and Psychiatric Epidemiology·Roisin DoyleMary Clarke
Nov 1, 2020·Nature Reviews. Cardiology·René Ernst NielsenSvend Eggert Jensen

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