PMID: 11312385Apr 20, 2001Paper

Mortality in rheumatoid arthritis: relationship to single and composite measures of disease activity

Rheumatology
J C ChehataP T Dawes

Abstract

Rheumatoid arthritis (RA) is a heterogeneous disease characterized by a variable course of remissions and relapses. Single measures of disease activity at only one point in time may not reflect the overall control of disease activity. The aim was to determine (i) the predictive value of 20 baseline demographic and disease variables on mortality, and (ii) the relationship between serial measures of the Stoke index (SI; a validated index of disease activity in RA) and mortality in RA. Mortality in 309 RA patients followed up for a median of 14 yr was analysed retrospectively. The standardized mortality ratio (SMR) was calculated for all causes of death. The predictive values of baseline and time-integrated variables were assessed using multivariate Cox proportional hazards regression analysis. The SMR was 1.65. At baseline, only nodules, erosions, RA latex titre, white cell count and globulin level were predictive of mortality after correction for age, sex and disease duration. Using a stepwise Cox proportional hazards regression model, the most powerful predictors of mortality were age, nodules and RA latex titre. Individual measures of disease activity and the SI at baseline were not predictive of mortality. However, the mean l...Continue Reading

Citations

Dec 25, 2007·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·G Kobelt, B Jönsson
Aug 14, 2003·Best Practice & Research. Clinical Rheumatology·Désirée van der Heijde
Jan 12, 2010·International Journal of Technology Assessment in Health Care·Ingrid LekanderRonald F van Vollenhoven
Apr 5, 2008·Current Opinion in Rheumatology·Maria I DanilaGim Gee Teng
Feb 28, 2007·Annals of the Rheumatic Diseases·Loreto CarmonaUNKNOWN BIOBADASER and EMECAR Groups
Oct 16, 2002·Annals of the Rheumatic Diseases·N Goodson, D Symmons
May 26, 2004·PharmacoEconomics·Tore K Kvien
Apr 17, 2009·Medicinski pregled·Biljana Obradović-TomasevićRatko Tomasević
May 25, 2010·Medicinski pregled·Biljana Obradović-TomasevićRatko Tomasević
Dec 24, 2005·Expert Opinion on Pharmacotherapy·Roy FleischmannRichard L Stern
Mar 30, 2012·Disability and Rehabilitation·Cornelia Antonia VerberktChristina H Opava
Nov 17, 2009·Current Medical Research and Opinion·Howard BirnbaumMary Cifaldi
Jan 29, 2011·Current Medical Research and Opinion·Iris GoetzKimberly L Sterling
Sep 18, 2003·Arthritis and Rheumatism·Gregorio Navarro-CanoAgustín Escalante
Feb 8, 2005·Arthritis and Rheumatism·Eva Eurenius, Christina H Stenström
Apr 9, 2008·The American Journal of Cardiology·Subhash BanerjeeSalahuddin Kazi
Sep 18, 2007·Best Practice & Research. Clinical Rheumatology·Sophia M Naz, Deborah P M Symmons
Aug 4, 2007·International Immunopharmacology·Mana MitamuraMine Kinoshita
Dec 8, 2015·Seminars in Arthritis and Rheumatism·Lydia AbasoloLuis Rodriguez-Rodriguez
Oct 27, 2015·Clinical Rheumatology·Yasser El Miedany
Oct 22, 2008·International Journal of Dermatology·Tulin ErgunHaner Direskeneli
Jul 14, 2010·Journal of Clinical Pharmacology·Chuanpu HuHonghui Zhou
Apr 15, 2010·Arthritis Care & Research·B J RadovitsR F J M Laan
Jul 17, 2013·Revista brasileira de reumatologia·Licia Maria Henrique da MotaUNKNOWN Colégio Brasileiro de Radiologia
Oct 4, 2016·Revista Brasileira De Reumatologia·Silvana Almeida RibasKatia Nunes Sá
Oct 9, 2009·Medicina intensiva·José Luis Escalante Cobo, Francisco Del Río Gallegos
Dec 17, 2004·Journal of Aging and Health·Nadine T JamesMichael Weaver
Apr 26, 2006·Lupus·D P M Symmons, A J Silman
Jun 10, 2003·Arthritis and Rheumatism·Frederick WolfeHyon K Choi
Mar 8, 2005·Arthritis and Rheumatism·Hilal Maradit-KremersSherine E Gabriel
Feb 15, 2002·Current Opinion in Rheumatology·Nicola Goodson

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