Mortality incidence among critically ill burn patients infected with multidrug-resistant organisms: A retrospective cohort study.

Scars, Burns & Healing
Moustafa EllithyKhaled Gazwi

Abstract

Many risk factors have been reported to increase mortality among burn patients. Previously, a higher mortality incidence was reported in acute burn patients infected with multidrug-resistant organisms (MDROs) when compared to patients infected with non-MDROs. However, considering this as an independent risk factor for mortality in acute burn patients is not yet confirmed. We conducted an observational retrospective study in Qatar. We included adult patients admitted to the surgical intensive care unit (ICU) between January 2015 and December 2017 with burn injuries involving either at least 15% of the total body surface area (TBSA) or less than 15% with facial involvement. All patients developed infection with a positive culture of either MDRO or non-MDRO. The primary outcome was in-hospital mortality. Other outcomes included days of mechanical ventilation, ICU, length of stay in hospital, and requirement of vasoactive agents. Fifty-eight patients were included in the final analysis: 33 patients in the MDRO group and 25 patients in the non-MDRO group. Six patients (18.2%) died in the MDRO group versus four patients (16%) in the non-MDRO group (P = 1). No significant difference was observed between the two groups with regard to t...Continue Reading

References

Mar 1, 1996·The Journal of Burn Care & Rehabilitation·P A Brigham, E McLoughlin
Feb 5, 1998·The New England Journal of Medicine·J R Saffle
May 21, 1999·Archives of Internal Medicine·Y CarmeliM H Samore
May 9, 2002·Burns : Journal of the International Society for Burn Injuries·R AnlaticiG Seydaoğlu
Mar 17, 2005·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Cheol-In KangKang-Won Choe
Mar 1, 2008·Journal of the American College of Surgeons·Roseanne A RessnerSteven E Wolf
Nov 21, 2008·Burns : Journal of the International Society for Burn Injuries·Rita GaleirasAndrés Esteban
Mar 26, 2009·Journal of the American College of Surgeons·Ruben GomezSteven E Wolf
Jun 2, 2009·Burns : Journal of the International Society for Burn Injuries·Jason WasiakBelinda Gabbe
Jul 29, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A-P MagiorakosD L Monnet
Dec 14, 2011·Antimicrobial Agents and Chemotherapy·Carmen PeñaUNKNOWN Spanish Network for Research in Infectious Diseases REIPI
Jul 3, 2013·Journal of Burn Care & Research : Official Publication of the American Burn Association·Panagiotis TheodorouVu T Q Phan
Apr 11, 2014·Trauma Monthly·Shahram FazeliBahare Safari-Faramani
Jan 7, 2015·Critical Care Medicine·Marc G JeschkeUNKNOWN Inflammation and the Host Response to Injury Collaborative Research Program
Dec 17, 2016·Journal of Burn Care & Research : Official Publication of the American Burn Association·Ilse van LangeveldMichael J Mosier
May 5, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Ignacio Barrasa-VillarJavier Moliner-Lahoz

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