Mortality, Morbidity, and Developmental Outcomes in Infants Born to Women Who Received Either Mefloquine or Sulfadoxine-Pyrimethamine as Intermittent Preventive Treatment of Malaria in Pregnancy: A Cohort Study

PLoS Medicine
María RupérezClara Menéndez

Abstract

Little is known about the effects of intermittent preventive treatment of malaria in pregnancy (IPTp) on the health of sub-Saharan African infants. We have evaluated the safety of IPTp with mefloquine (MQ) compared to sulfadoxine-pyrimethamine (SP) for important infant health and developmental outcomes. In the context of a multicenter randomized controlled trial evaluating the safety and efficacy of IPTp with MQ compared to SP in pregnancy carried out in four sub-Saharan countries (Mozambique, Benin, Gabon, and Tanzania), 4,247 newborns, 2,815 born to women who received MQ and 1,432 born to women who received SP for IPTp, were followed up until 12 mo of age. Anthropometric parameters and psychomotor development were assessed at 1, 9, and 12 mo of age, and the incidence of malaria, anemia, hospital admissions, outpatient visits, and mortality were determined until 12 mo of age. No significant differences were found in the proportion of infants with stunting, underweight, wasting, and severe acute malnutrition at 1, 9, and 12 mo of age between infants born to women who were on IPTp with MQ versus SP. Except for three items evaluated at 9 mo of age, no significant differences were observed in the psychomotor development milestones...Continue Reading

References

Sep 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·A M GreenwoodB M Greenwood
Sep 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·B M GreenwoodA B Hatib-N'Jie
Mar 1, 1994·The Journal of Infectious Diseases·F NostenN J White
Jan 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P NyirjesyP R Fischer
Feb 6, 1998·The American Journal of Tropical Medicine and Hygiene·B VanhauwereL Kerr
May 24, 2000·The Journal of Infectious Diseases·C MenendezP L Alonso
May 29, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F NostenN J White
Jun 27, 2001·The American Journal of Tropical Medicine and Hygiene·R W SteketeeC Menendez
Sep 5, 2001·American Journal of Epidemiology·C LuxemburgerF Nosten
Nov 22, 2001·The American Journal of Tropical Medicine and Hygiene·T PlancheP G Kremsner
Feb 6, 2002·Journal of Tropical Pediatrics·O F Aina, O Morakinyo
Sep 21, 2002·Lancet·C E ShulmanJ N Bulmer
Jan 24, 2004·Acta Tropica·M RamharterP G Kremsner
Mar 23, 2004·American Journal of Epidemiology·Guangyong Zou
Jun 10, 2004·Annals of Tropical Paediatrics·Francine H VerhoeffBernard J Brabin
Aug 24, 2004·Archives of Disease in Childhood·C M WrightR F Drewett
Oct 19, 2004·Clinical Microbiology Reviews·Helen L Guyatt, Robert W Snow
Oct 30, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A SowunmiA O Arowojolu
Oct 20, 2005·The Journal of Infectious Diseases·Anne-Catrin UhlemannSanjeev Krishna
Jan 26, 2007·The Lancet Infectious Diseases·Meghna DesaiRobert D Newman
Jan 26, 2007·The Lancet Infectious Diseases·Clara MenéndezFeiko O ter Kuile
May 8, 2007·Seminars in Fetal & Neonatal Medicine·Clara Menendez, Alfredo Mayor
Jun 29, 2007·Tropical Medicine & International Health : TM & IH·Agnès AubouyPhilippe Deloron
Aug 12, 2008·Current Drug Safety·François NostenBernard Brabin
Sep 11, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Norbert G SchwarzMartin P Grobusch
Dec 24, 2008·BMC Public Health·Ingunn Marie Stadskleiv EngebretsenJames K Tumwine
Mar 3, 2010·PloS One·Clara MenéndezPedro L Alonso
Jan 5, 2011·The Journal of Infectious Diseases·Azucena BardajíClara Menéndez
Aug 6, 2011·Malaria Journal·Christine SwysenUNKNOWN Clinical Trials Partnership Committee
Jan 13, 2012·The American Journal of Clinical Nutrition·Idoia LabayenMichael Sjostrom
Apr 13, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patricia SchlagenhaufMiriam Adamcova
Apr 24, 2012·Tropical Medicine & International Health : TM & IH·C BeiersmannO Müller
May 11, 2012·Annals of Nutrition & Metabolism·Hildegard Przyrembel
Jun 19, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Lise Denoeud-NdamMichel Cot
Sep 28, 2012·Nutrients·Siân Robinson, Caroline Fall
Dec 4, 2012·International Journal of Environmental Research and Public Health·Amina AbubakarBabill Stray-Pedersen

❮ Previous
Next ❯

Citations

Nov 27, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Abraham Sunday AlabiUNKNOWN CERMEL TB CapDev Group
Mar 22, 2018·The Cochrane Database of Systematic Reviews·Raquel GonzálezClara Menéndez
May 3, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Oriyomi AkinyotuAyodele Arowojolu
Jul 19, 2018·Parasite Immunology·Whitney E HarringtonPrasanna Jagannathan
Nov 28, 2018·The Cochrane Database of Systematic Reviews·Raquel GonzálezClara Menéndez
Nov 30, 2018·BMC Infectious Diseases·Isaiah GwitiraMhosisi Masocha

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT00811421

Software Mentioned

OpenClinica Enterprise
Stata

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.