Mortality of neuromyelitis optica spectrum disorders in a Chinese population.

Annals of Clinical and Translational Neurology
Qin DuHongyu Zhou

Abstract

Neuromyelitis optica spectrum disorder (NMOSD) is a rapidly disabling disease. Epidemiologic studies have suggested varying NMOSD mortality across ethnic groups. However, NMOSD mortality data in China are scarce. This study's objectives were to explore mortality and causes of death among Chinese NMOSD patients and to identify independent predictors of death. We performed a retrospective study with a 10-year follow-up of Chinese NMOSD patients. A Cox proportional hazards model was used to identify independent predictors of death. Five hundred and sixty-nine patients were included; 24 patients died during follow-up, for overall mortality of 4.2%. In these patients, the median disease duration at the time of death was 3.4 years. The most common cause of death was secondary infection (62.5%), especially respiratory infection (45.8%). The second most common cause of death was extensive cervical myelitis with respiratory failure (16.7%). Other causes included suicide (8.3%), cancer (4.2%), cerebral embolism (4.2%), and unknown causes (4.2%). The multivariate Cox analyses indicated that a short first interattack interval (HR = 0.93, 95% CI 0.89-0.98, p = 0.003), lack of regular immunotherapy (HR = 10.34, 95% CI 4.05-26.37, p < 0.001),...Continue Reading

References

Aug 1, 1991·Neurology·A D SadovnickD W Paty
Sep 25, 1999·Neurology·D M WingerchukB G Weinshenker
Mar 12, 2003·Neurology·Dean M Wingerchuk, Brian G Weinshenker
Feb 13, 2004·Brain : a Journal of Neurology·Henrik Brønnum-HansenEgon Stenager
May 24, 2006·Neurology·D M WingerchukB G Weinshenker
Sep 19, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·P CabreJ A Cabrera-Gomez
Apr 23, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Elsebeth Nylev StenagerEgon Stenager
Jan 19, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Sung-Min KimKwang-Woo Lee
Dec 11, 2013·Multiple Sclerosis : Clinical and Laboratory Research·N CollonguesJ De Seze
Apr 30, 2015·Multiple Sclerosis : Clinical and Laboratory Research·L PanditUNKNOWN GJCF International Clinical Consortium & Biorepository for Neuromyelitis Optica
Jun 5, 2015·Multiple Sclerosis : Clinical and Laboratory Research·In Hye JeongHo Jin Kim
Jun 21, 2015·Neurology·Dean M WingerchukUNKNOWN International Panel for NMO Diagnosis
Jan 3, 2016·Journal of the Neurological Sciences·Perry MooreAnu Jacob
Oct 27, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H ChenH Zhou
May 28, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Wajih BukhariSimon A Broadley
Nov 11, 2017·Multiple Sclerosis and Related Disorders·V C FernándezA M Villa
Mar 23, 2018·Journal of Neurology·Astrid EliasenHenrik Horwitz
Jun 13, 2018·Neurology. Neuroimmunology and Neuroinflammation·Maureen A MealyMichael Levy
Oct 28, 2018·Neurology·Su-Hyun KimHo Jin Kim
Apr 3, 2019·Brain : a Journal of Neurology·Jacqueline PalaceSean J Pittock
Apr 7, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Sara MariottoAlberto Gajofatto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Xiaonan ZhongWei Qiu
Multiple Sclerosis and Related Disorders
Correa-Díaz Edgar PatricioGualotuña Pachacama Wilson Alfredo
Current Opinion in Rheumatology
Andrew R Romeo, Benjamin M Segal
© 2021 Meta ULC. All rights reserved