Mortality Outcomes of Patients with Chronic Kidney Disease and Chronic Obstructive Pulmonary Disease

American Journal of Nephrology
Sankar D NavaneethanJoseph V Nally

Abstract

Chronic obstructive pulmonary disease (COPD) is associated with higher mortality in the general population. We studied the associations between COPD and death among chronic kidney disease (CKD) patients along with reporting cause-specific death data. We included 56,960 patients with stages 3 and 4 CKD who were followed in a large health care system. Associations between COPD and all-cause mortality and various causes of death (respiratory deaths, cardiovascular deaths, malignancy-related deaths and deaths due to other reasons) were studied using the Cox proportional hazards and competing risk models. Out of 56,960 CKD patients, 4.7% (n = 2,667) had underlying COPD. Old age, presence of diabetes, hypertension, coronary artery disease, congestive heart failure, and smoking were associated with higher risk for COPD. During a median follow-up of 3.7 years, 15,969 patients died. After covariate adjustment, COPD was associated with a 41% increased risk (95% CI 1.31-1.52) for all-cause mortality, and fourfold increased risk (sub-hazard ratio 4.36, 95% CI 3.54-5.37) for respiratory-related deaths. In a sensitivity analysis that was performed by defining COPD as the use of relevant International Classification of Diseases-9 codes and me...Continue Reading

Citations

Jun 6, 2019·Revista da Associação Médica Brasileira·César Calvo-LoboJesús Seco-Calvo
Aug 21, 2020·PloS One·Elizabeth G BondUNKNOWN Canadian Respiratory Research Network
Nov 21, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cécile CouchoudGuillaume Jean
Sep 24, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Elif KayaReza Wakili
Apr 8, 2017·International Urology and Nephrology·Min Young KimNa Ree Kang
Jul 14, 2019·Respiratory Research·Franziska C TrudzinskiUNKNOWN German COSYCONET consortium
Dec 8, 2020·American Journal of Physiology. Renal Physiology·Danielle L KirkmanAntonio Abbate

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