Mortality Prediction in the Oldest Old with Five Different Equations to Estimate Glomerular Filtration Rate: The Health and Anemia Population-based Study

PloS One
Sara MandelliUgo Lucca

Abstract

Kidney function declines considerably with age, but little is known about its clinical significance in the oldest-old. To study the association between reduced glomerular filtration rate (GFR) estimated according to five equations with mortality in the oldest-old. Prospective population-based study. Municipality of Biella, Piedmont, Italy. 700 subjects aged 85 and older participating in the "Health and Anemia" Study in 2007-2008. GFR was estimated using five creatinine-based equations: the Cockcroft-Gault (C-G), Modification of Diet in Renal Disease (MDRD), MAYO Clinic, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Berlin Initiative Study-1 (BIS-1). Survival analysis was used to study mortality in subjects with reduced eGFR (<60 mL/min/1.73 m(2)) compared to subjects with eGFR ≥ 60 mL/min/1.73 m(2). Prevalence of reduced GFR was 90.7% with the C-G, 48.1% with MDRD, 23.3% with MAYO, 53.6% with CKD-EPI and 84.4% with BIS-1. After adjustment for confounders, two-year mortality was significantly increased in subjects with reduced eGFR using BIS-1 and C-G equations (adjusted HRs: 2.88 and 3.30, respectively). Five-year mortality was significantly increased in subjects with eGFR <60 mL/min/1.73 m(2) using MAYO, CKD-...Continue Reading

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Software Mentioned

MAYO
Stata IC
JMP Pro

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