Mortality Risk Detected by Atherosclerotic Cardiovascular Disease Score in Patients With Nonalcoholic Fatty Liver Disease

Hepatology Communications
Pegah GolabiZobair M Younossi

Abstract

Cardiovascular diseases (CVDs) are the leading cause of mortality in patients with nonalcoholic fatty liver disease (NAFLD). Our aim was to assess the association of atherosclerotic cardiovascular disease (ASCVD) risk scores with overall and cardiac-specific mortality among patients with NAFLD. We used the National Health and Nutrition Examination Survey III with the National Death Index-linked mortality files. NAFLD was defined by ultrasound as presence of steatosis in the absence of secondary causes of liver disease. High risk for CVD was defined as a 10-year ASCVD score ≥7.5%. Hazard ratios (HRs) and population-attributable fractions (PAFs) of high risk for CVD were calculated. Among 1,262 subjects with NAFLD (47.9% men; 41.2% white; mean age, 56.3 years), the prevalence of high risk for CVD was 55.9% and 4.8% had advanced fibrosis. After a median follow-up of 17.7 years, 482 subjects (38.2%) died of overall causes, of whom 382 (79.3%) had a high risk for CVD. The unadjusted overall and cardiac-specific mortality were higher for patients with NAFLD who had a high risk for CVD compared to subjects with NAFLD with a low risk for CVD (57.3% vs. 16.8% for overall mortality; 16.4% vs. 3.5% for cardiovascular mortality). After con...Continue Reading

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Citations

Nov 30, 2019·Alimentary Pharmacology & Therapeutics·James M PaikZobair M Younossi
Dec 5, 2019·Digestive Diseases and Sciences·Christian LabenzJörn M Schattenberg
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Jun 13, 2021·Journal of Internal Medicine·Hannes HagströmMattias Ekstedt
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Aug 9, 2021·Obesity·Fasiha KanwalKenneth Cusi
Aug 22, 2021·Gastroenterology·Fasiha KanwalKenneth Cusi
Jul 28, 2021·Diabetes Care·Fasiha KanwalKenneth Cusi
Sep 1, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Zobair M YounossiMaria Stepanova

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Methods Mentioned

BETA
blood draws
biopsies

Software Mentioned

SAS

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