Mortality selection in a genetic sample and implications for association studies

International Journal of Epidemiology
Benjamin W DomingueJason D Boardman


Mortality selection occurs when a non-random subset of a population of interest has died before data collection and is unobserved in the data. Mortality selection is of general concern in the social and health sciences, but has received little attention in genetic epidemiology. We tested the hypothesis that mortality selection may bias genetic association estimates, using data from the US-based Health and Retirement Study (HRS). We tested mortality selection into the HRS genetic database by comparing HRS respondents who survive until genetic data collection in 2006 with those who do not. We next modelled mortality selection on demographic, health and social characteristics to calculate mortality selection probability weights. We analysed polygenic score associations with several traits before and after applying inverse-probability weighting to account for mortality selection. We tested simple associations and time-varying genetic associations (i.e. gene-by-cohort interactions). We observed mortality selection into the HRS genetic database on demographic, health and social characteristics. Correction for mortality selection using inverse probability weighting methods did not change simple association estimates. However, using th...Continue Reading


Oct 19, 2017·International Journal of Epidemiology·Marcus R MunafòGeorge Davey Smith
Jun 21, 2019·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lauren L SchmitzErin B Ware
Aug 3, 2019·Epidemiology·Roelof A J SmitSaskia le Cessie
May 29, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Rachel F BuckleyHarvard Aging Brain Study
Oct 17, 2019·BMC Public Health·Carmen D Ng, Jordan Weiss
Jul 31, 2020·Biodemography and Social Biology·Guangyu Tong, Guang Guo
May 14, 2019·Evolutionary Applications·Peeter HõrakTanel Kaart
May 20, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Mika D ThompsonYan Yan Wu
Jan 10, 2019·Communications Biology·Melinda Mills, Charles Rahal
Jul 31, 2019·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Brooke M HuibregtseJason D Boardman


Feb 1, 1995·Journal of Epidemiology and Community Health·D A LeonDavid P Strachan
Oct 5, 2002·Chemosphere·A SmolińskiJ W Einax
Apr 2, 2005·Nature Reviews. Genetics·David J Hunter
Sep 6, 2007·Genome Research·Naomi R WrayPeter M Visscher
Nov 8, 2007·JAMA : the Journal of the American Medical Association·Katherine M FlegalMitchell H Gail
Apr 27, 2010·Nature Genetics·Tobacco and Genetics Consortium
Apr 28, 2010·Journal of Health and Social Behavior·Jason D BoardmanFred C Pampel
Dec 3, 2010·The New England Journal of Medicine·Amy Berrington de GonzalezMichael J Thun
Jan 12, 2011·Statistical Methods in Medical Research·Shaun R Seaman, Ian R White
Apr 5, 2013·PLoS Genetics·Frank Dudbridge
Jan 11, 2014·Annual Review of Psychology·Stephen B Manuck, Jeanne M McCaffery
Jul 31, 2014·Population Research and Policy Review·Anna Zajacova, Sarah A Burgard
Aug 16, 2014·International Journal of Epidemiology·Amy E TaylorCARTA consortium
Oct 8, 2014·Psychological Science·Cornelius A RietveldSocial Science Genetics Association Consortium
Feb 3, 2015·Epidemiology·Anna G C BoefOlaf M Dekkers
Feb 13, 2015·Nature·Adam E LockeElizabeth K Speliotes
Feb 19, 2015·Epidemiology·Eric J Tchetgen TchetgenM Maria Glymour
Aug 1, 2015·Behavior Genetics·Benjamin W DomingueJason D Boardman
Sep 12, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Morgan E Levine, Eileen M Crimmins
Feb 6, 2016·American Journal of Human Genetics·Felix R DayJohn R B Perry
Apr 12, 2016·Genetic Epidemiology·Frank Dudbridge
Jun 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Dalton ConleyBenjamin W Domingue
Jul 6, 2016·JAMA : the Journal of the American Medical Association·Stefan WalterM Maria Glymour
Jul 10, 2016·Demography·Petter LundborgPaul Nystedt
Jul 13, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jonathan P Beauchamp
Jul 28, 2016·Scientific Reports·Dalton ConleyBenjamin W Domingue
Nov 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Riccardo E MarioniIan J Deary

Related Concepts

Truncation Biases
Mental Health Wellness 1
Kaplan-Meier Estimate
Cessation of Life
Weighing Patient
Genetic Association Studies
Genetic Sample

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.