PMID: 8611354Feb 1, 1996Paper

Mortality trends in pediatric patients with chronic renal failure

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
U ReissK Schärer

Abstract

Mortality trends were analyzed in 441 children and adolescents with chronic renal failure (CRF) observed over a 24-year period before and after institution of renal replacement therapy (RRT). A total of 93 patients died. Overall mortality rate (MR) per 100 patient years decreased from 6.6 in 1969-1978 to 2.5 in 1979-1988 and increased slightly to 2.9 in 1989-1992. The fall involved all four modes of treatment: conservative, hemodialysis (HD), continuous peritoneal dialysis (CPD), and transplantation (TX). From 1979-1988 to 1989-1992 MR on conservative and on dialysis treatment changed only slightly and was similar on HD and CPD. An alarming rise in MR was noted after TX in 1989-1992, mainly due to malignant tumors. In 44 patients who died on conservative treatment, the reasons for non-acceptance for RRT were analyzed: in 22 multi-morbidity was the main reason, usually because of a congenital neurological disorder. Some patients died from advanced uremia or unexpected events after the decision to institute RRT. Our experience demonstrates a persistent mortality in pediatric patients with CRF, which in recent years is primarily ascribed to congenital multi-morbid conditions which make RRT unfeasible, infections on dialysis treatm...Continue Reading

References

Jul 1, 1992·The Journal of Pediatrics·U QuerfeldK Schärer
May 1, 1992·Journal of Pediatric Surgery·C A SheldonG S Arbus
Jan 1, 1988·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F P BrunnerA J Wing
Mar 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D J HirschK K Jindal
Dec 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M BroyerK Schärer
Jan 1, 1993·European Journal of Pediatrics·K SchärerW Rascher
Jul 1, 1994·Journal of Postgraduate Medicine·P A Morrin

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Citations

Apr 9, 2011·European Journal of Pediatrics·Gabriel KolvekJitse P van Dijk
Oct 26, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Julie R Ingelfinger
Feb 19, 2002·Kidney International·Jaap W GroothoffHugo S A Heymans
Apr 14, 1999·Kidney International·G OffnerJ Brodehl
Sep 29, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C S WongC Stehman-Breen
Jun 25, 2004·Advances in Chronic Kidney Disease·Rita D Swinford, Ronald J Portman
Sep 5, 2001·Advances in Renal Replacement Therapy·S L FurthB A Fivush
Mar 4, 2014·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Krystyna Laszki-SzczachorMalgorzata Sobieszczanska
Oct 8, 1998·The Annals of Pharmacotherapy·P S Smith

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