Morules in cribriform-morular variant of papillary thyroid carcinoma: Immunohistochemical characteristics and distinction from squamous metaplasia

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Mitsuyoshi HirokawaKennichi Kakudo

Abstract

Morules are a diagnostic clue to the cribriform-morular variant (C-MV) of papillary thyroid carcinoma, and are superficially similar to squamous metaplasia. In order to clarify the histogenesis of morules and differentiate them from squamous metaplasia, we immunohistochemically compared the morules in five cases of C-MV with squamous metaplasia in six cases of diffuse sclerosing variant (DSV) of papillary thyroid carcinoma. The squamous metaplastic cells were immunopositive for low- and high-molecular-weight cytokeratin, whereas the morular cells were negative or focally positive. Vimentin-positive cells were observed focally in the morules and squamous metaplasia, except for one case of CMV that showed intense positivity. The morular cells showed weak cytoplasmic positivity for beta-catenin, and the cell membrane was not highlighted. Some nuclei of the morular cells were also positive for this antibody. Beta-catenin was intensively positive along the cell membrane of the metaplastic cells, and did not react against the nuclei or cytoplasm. Bcl-2 was positive in the morular cells, but negative in the metaplastic cells. S-100 protein-positive dendritic cells were observed in the metaplastic nests, but not in the morules. We argu...Continue Reading

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Citations

Sep 10, 2005·Expert Review of Molecular Diagnostics·Jennifer L Hunt
Nov 1, 2005·Expert Review of Molecular Diagnostics·Orla Sheils
Aug 22, 2015·Pathology, Research and Practice·Dinesh PradhanSambit K Mohanty
May 23, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·José Manuel Cameselle-TeijeiroManuel Sobrinho-Simões
Jul 22, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Silvia ChiarelliFrancisco F Nogales

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