PMID: 9552420Jan 1, 1997Paper

Mos and the cell cycle

Progress in Cell Cycle Research
B Singh, R Arlinghaus

Abstract

The mos proto-oncogene-encoded serine/threonine protein kinase plays a key cell cycle-regulatory role during meiosis. The Mos protein is required for the activation and stabilisation of M phase-promoting factor MPF. As a component of a large multiprotein complex known as the cytostatic factor (CSF), Mos is involved in causing metaphase II arrest of eggs in vertebrates. Upon expression in somatic cells, Mos causes cell cycle perturbations resulting in cytotoxicity and neoplastic transformation. All the known biological activities of Mos are mediated through activation of the mitogen activated protein (MAP) kinase pathway. Here we discuss the interrelationship between Mos and other cell cycle regulators.

Citations

Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·S L JinM Conti
Jan 22, 2004·Molecular Reproduction and Development·Kirsten C SadlerAndré Picard
Aug 10, 2000·Histopathology·A AthanasiouC Kittas
Nov 12, 2003·American Journal of Clinical Pathology·Athanasios AthanasiouSeth Love
May 8, 2001·Experimental Cell Research·J F BodartS Flament

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