MoS2 @polydopamine-Ag nanosheets with enhanced antibacterial activity for effective treatment of Staphylococcus aureus biofilms and wound infection

Nanoscale
Lihui YuwenLianhui Wang

Abstract

Developing novel antibacterial agents to combat bacterial infection has been an everlasting task for scientists, due to the drug resistance evolved by bacteria during antibiotic treatment. In this work, we used polydopamine (PDA) to modify MoS2 nanosheets (MoS2 NSs) and then grew silver nanoparticles (AgNPs) on their surface to form MoS2@PDA-Ag nanosheets (MPA NSs) as multimodal antibacterial nanoagents to treat Staphylococcus aureus (S. aureus) biofilms and S. aureus infected wounds. In vitro results show that treatment with MPA NSs under near-infrared (NIR) laser irradiation can efficiently eradicate the established S. aureus biofilms with 99.99% of the bacteria inside biofilms killed, which shows significantly enhanced therapeutic efficacy compared with the MPA only group or the NIR laser irradiation only group. Remarkably, MPA NSs were also successfully used to treat S. aureus infected wounds in mice under NIR laser irradiation. In vivo experiments demonstrate that about 99% of bacteria in wounds were killed and the healing of the infected wounds was promoted. Overall, this work demonstrates that MPA NSs with enhanced antibacterial activity are promising nanoagents to treat S. aureus biofilms and S. aureus infected wounds.

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Citations

Aug 21, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Dong-Hui ZhaoBo Liu
Sep 26, 2019·Frontiers in Bioengineering and Biotechnology·Yuqian ZhangLianhui Wang
Jun 11, 2020·Nanomaterials·Sibidou YougbaréTsung-Rong Kuo
Jul 1, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jinping ShiCan Yang Zhang
Oct 30, 2020·Frontiers in Bioengineering and Biotechnology·Manjot SinghCarlo Altucci
Jun 11, 2020·Molecular Pharmaceutics·Shahriar SharifiMorteza Mahmoudi
Jan 30, 2021·Frontiers in Microbiology·Indu SinghPradeep Kumar
Mar 2, 2021·International Journal of Biological Macromolecules·Kasirajan KasinathanStephen Rajkumar Inbanathan Savariroyan
Apr 8, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yuqian ZhangYang Li
Jul 24, 2021·International Journal of Nanomedicine·Juanjuan XuGaofeng Liang
Apr 15, 2020·ACS Applied Materials & Interfaces·Mohsin AminKathryn A Whitehead

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Methods Mentioned

BETA
transmission
atomic force microscopy
dynamic light scattering
X-ray
irradiate

Software Mentioned

FV10
ASW

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