Mosaic and polymorphic imprinting of the WT1 gene in humans

Nature Genetics
Y JinnoN Niikawa

Abstract

We have examined the imprinting of the Wilms' tumour suppressor gene (WT1) in human tissues. We confirm that WT1 is biallelically expressed in the kidney, however, in five of nine preterm placentae WT1 was expressed largely or exclusively from the maternal allele. Monoallelic expression of WT1 was also found in two fetal brains. These data demonstrate that WT1 can undergo tissue specific imprinting. Furthermore, because monoallelic expression of WT1 was not found in all placentae examined, WT1 imprinting may be genetically polymorphic within the human population.

References

Apr 1, 1992·Nature Genetics·Y Zhang, B Tycko
Jan 1, 1992·Trends in Genetics : TIG·V Van Heyningen, N D Hastie
Apr 1, 1992·Genomics·M GesslerG A Bruns
Mar 11, 1991·Nucleic Acids Research·P R Hoban, A M Kelsey
Feb 22, 1991·Cell·T M DeChiaraA Efstratiadis
Jan 1, 1990·Molecular Carcinogenesis·C Sapienza
Apr 1, 1982·The Journal of Pediatrics·V M RiccardiR E Ferrell
May 1, 1993·Nature Genetics·N GiannoukakisC Polychronakos
Apr 22, 1993·Nature·S RainierA P Feinberg
Aug 27, 1993·Cell·J A KreidbergR Jaenisch

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Citations

Mar 1, 1997·Molecular Reproduction and Development·L H LooijengaJ W Oosterhuis
Nov 2, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Maria A SmitCarole Charlier
Apr 30, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Sylvie CroteauAnna K Naumova
Jul 1, 1996·Cancer Genetics and Cytogenetics·M L GlassmanA Hochberg
Jun 1, 1994·Trends in Genetics : TIG·D P Barlow
May 16, 1996·Biochimica Et Biophysica Acta·J C Reddy, J D Licht
Jun 1, 1994·Current Opinion in Cell Biology·M A Surani
Jan 22, 1998·Mutation Research·G L Mutter
Jan 1, 1996·Placenta·G C FranklinR Ohlsson
Sep 5, 1998·Brain Research. Molecular Brain Research·R BunzelM M Nöthen
May 14, 1999·Trends in Ecology & Evolution·H G SpencerM W Feldman
Dec 1, 1996·Blood Reviews·B H RamsahoyeK I Mills
Jun 1, 1996·Current Opinion in Cell Biology·R M John, M A Surani
Aug 23, 2002·Seminars in Cancer Biology·Andrew P FeinbergRolf Ohlsson
Jan 8, 1999·Mutation Research·D J PulfordR L Jirtle
Jan 1, 1996·Eye·S A SadiqR M Gregson
Mar 1, 1994·Nature Genetics·M S Bartolomei
Jan 11, 2007·European Journal of Human Genetics : EJHG·Elke GeunsMartine De Rycke
May 1, 1997·Human Molecular Genetics·S KobayashiF Ishino
Aug 6, 2008·Human Molecular Genetics·Layla Parker-KatiraeeStephen W Scherer
Jul 11, 2001·Genome Génome / Conseil National De Recherches Canada·A K NaumovaK Morgan
Jan 1, 1996·Annual Review of Genetics·M Lalande
Jan 1, 1997·Annual Review of Genetics·M S Bartolomei, S M Tilghman
Apr 2, 2013·The Journal of Clinical Investigation·Athar AzizAnthony R Green
Oct 22, 2010·The Journal of Clinical Endocrinology and Metabolism·Liis UuskülaMaris Laan
Mar 4, 2000·Environmental Health Perspectives·S K Murphy, R L Jirtle
Feb 1, 2010·Epigenomics·Isabelle Cui, Hengmi Cui
Nov 30, 2011·Epigenomics·Boris Novakovic, Richard Saffery
Aug 31, 2001·Biochemical and Biophysical Research Communications·J A McCannC Polychronakos
May 18, 2001·Biochemical and Biophysical Research Communications·T SakataniM Oshimura
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·John M Greally
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·L Carrel, H F Willard
Aug 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Elena AllenYork Marahrens

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