journal cover

Mosaic Epigenetic Dysregulation of Ectodermal Cells in Autism Spectrum Disorder

bioRxiv

May 6, 2014

Esther R BerkoJohn M Greally

Abstract

DNA mutational events are increasingly being identified in autism spectrum disorder (ASD), but the potential additional role of dysregulation of the epigenome in the pathogenesis of the condition remains unclear. The epigenome is of interest as a possible mediator of environmental effec...read more

Mentioned in this Paper

Assay
Autism Spectrum Disorders
Epigenetic Process
Study of Epigenetics
Memory
Aneuploidy
Silver
Study
Gametes
DNA Methylation
6
1
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

Gastrulation

Gastrulation is a phase early in the embryonic development of most animals, during which the single-layered blastula is reorganized into a multilayered structure known as the gastrula. Before gastrulation, the embryo is a continuous epithelial sheet of cells; by the end of gastrulation, the embryo has begun differentiation to establish distinct cell lineages, set up the basic axes of the body, and internalized one or more cell types including the prospective gut

Chromosomal Duplication

Chromosomal duplication is a result of extra genetic material within the area of the chromosome. The duplication may have no effect or may be expressed in the phenotype of that individual. Some duplications are thought to be of evolutionary selection. Discover the latest research on chromosomal duplication here.

DNA Methylation

DNA methylation is an epigenetic mechanism of gene regulation, and dysregulation of DNA methylation has been associated with tumorigenesis. Discover the latest research on DNA methylation here.

Chromosomal Abnormalities

Chromosome abnormalities can be classified as either structural or numerical. Numerical abnormalities include duplications or deletion of a pair of chromosomes, such as Down Syndrome. Structural abnormalities include missing, extra or switched parts of a chromosome. Discover the latest research on chromosomal abnormalities here.

Nonseminomatous Testicular Germ Cell Tumors

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Epigenetics & Aging (Keystone)

Epigenetic changes, such as changes in histone modification patterns and noncoding RNA expression levels, have a strong influence on the aging process. Discover new insights into the role of epigenetics in aging in this feed.

Epigenetics (Preprints)

Epigenetics is the study of heritable changes in gene expression that do not involve alteration of the DNA sequence. Here are the latest preprints in epigenetics.

Epigenetics

Epigenetics is the study of heritable changes in gene expression that do not involve alteration of the DNA sequence. Here is the latest research.

Nuclear Architecture

The 3-D organization of chromatin is an important factor in the regulation of gene expression. Find the latest research on nuclear architecture here.

Epigenetic Clocks (Keystone)

Aging is associated with reproducible changes in DNA methylation, and this epigenetic aging signature can be used to predict biological age. Find the latest research on epigenetic clocks here.

Cell Aging

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Chromatin Remodeling

Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying chromatin remodeling.

Epigenetic Clocks

Aging is associated with reproducible changes in DNA methylation, and this epigenetic aging signature can be used to predict biological age. Find the latest research on epigenetic clocks here.

Aging Genetics

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Genomic Instability & Aging

During aging, it has been shown that genomic instability increases. This leads to mutations, cellular dysfunction, mitochondrial DNA damage, which may increase the risk for neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and ALS. Here is the latest research on genomic instability associated with aging.

Genomic Instability & Aging (Keystone)

During aging, it has been shown that genomic instability increases. This leads to mutations, cellular dysfunction, and mitochondrial DNA damage, which may increase the risk for neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and ALS. Here is the latest research on genomic instability associated with aging.

BioRxiv Preprints

BioRxiv is the preprint server for biology, operated by Cold Spring Harbor Laboratory. Here are the latest biology preprint articles from bioRxiv.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research.

Neurogenetic Disorders

Neurogenetic disorders are caused by a defect in one or more genes affecting the differentiation and function of the neuroectoderm and its derivatives. Here is the latest research on neurogenetic disorders

Chromatin Remodeling (Keystone)

Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying this process.

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Nuclear Architecture (Keystone)

The 3-D organization of chromatin is an important factor in the regulation of gene expression. Find the latest research on nuclear architecture in this feed.

Chromatin Remodelling

Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying chromatin remodeling.

Embryogenesis

Embryogenesis is the process by which the embryo forms and develops. It starts with the fertilization of the egg cell (ovum) by a sperm cell, (spermatozoon). Once fertilized, the ovum is referred to as a zygote, a single diploid cell. The zygote undergoes mitotic divisions with no significant growth (a process known as cleavage) and cellular differentiation, leading to development of a multicellular embryo

DNA Methylation (Keystone)

DNA methylation is an epigenetic mechanism of gene regulation, and dysregulation of DNA methylation has been associated with tumorigenesis. Discover the latest research on DNA methylation here.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Epigenetics & Aging

Epigenetic changes, such as changes in histone modification patterns and noncoding RNA expression levels, have a strong influence on the aging process. Discover new insights into the role of epigenetics in aging in this feed.

Epigenetics (Keystone)

Epigenetics is the study of heritable changes in gene expression that do not involve alteration of the DNA sequence. Here is the latest research.

Cell Aging (Preprints)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Gene Regulation, Epigenetics, & Aging (Keystone)

Epigenetic and genetic factors influence aging processes and age-associated diseases. Manipulation of epigenetic changes may prove to be a useful therapeutic tool. Find the latest research relating to Shelley Berger's talk on "Epigenetic Pathways as Targets in Human Cancer" in this feed.

© 2020 Meta ULC. All rights reserved

Mosaic Epigenetic Dysregulation of Ectodermal Cells in Autism Spectrum Disorder

bioRxiv

May 6, 2014

Esther R BerkoJohn M Greally

PMID: 990004853

DOI: 10.1101/004853

Abstract

DNA mutational events are increasingly being identified in autism spectrum disorder (ASD), but the potential additional role of dysregulation of the epigenome in the pathogenesis of the condition remains unclear. The epigenome is of interest as a possible mediator of environmental effec...read more

Mentioned in this Paper

Assay
Autism Spectrum Disorders
Epigenetic Process
Study of Epigenetics
Memory
Aneuploidy
Silver
Study
Gametes
DNA Methylation
6
1

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
/papers/mosaic-epigenetic-dysregulation-of-ectodermal/990004853