Mössbauer investigations of high-spin ferrous heme proteins. II. Chloroperoxidase, horseradish peroxidase, and hemoglobin.

Biochemistry
P M ChampionL P Hager

Abstract

Reduced samples of chloroperoxidase, horseradish peroxidase, and deoxyhemoglobin were studied by Mössbauer spectroscopy in strong magnetic fields. The intricate paramagnetic spectra of chloroperoxidase were evaluated in detail in the framework of a spin Hamiltonian pertinent to high-spin ferrous iron. The studies strongly suggest that, in their reduced states, chloroperoxidase from Caldariomyces fumago and cytochrome P-450 from Pseudomonas putida have similar, if not identical ligand structures of the heme iron. The spectral similarities of these two proteins, noted in an earlier Mössbauer investigation, are further explored and substantiated. Reduced horseradish peroxidase and deoxyhemoglobin, on the other hand, show high-field Mössbauer spectra that differ considerably from each other and, in particular, from those of the P-450 type, suggesting a different ligand arrangement of the heme iron for each case.

References

Aug 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·R TsaiH Beinert
Dec 3, 1971·Biochemical and Biophysical Research Communications·R L TsaiK Dus
Jan 30, 1973·Biochemistry·P M ChampionL P Hager
Mar 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·D DolphinR H Felton
Dec 1, 1952·Archives of Biochemistry and Biophysics·B CHANCE
Oct 1, 1959·Biochimica Et Biophysica Acta·F W TEALE

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Citations

Oct 28, 1976·Biochimica Et Biophysica Acta·P M ChampionL P Hager
Nov 25, 1977·Biochimica Et Biophysica Acta·M H EmptageW H Orme-Johnson
Jan 1, 1978·Progress in Biophysics and Molecular Biology·S A Fairhurst, L H Sutcliffe
Dec 18, 2001·Journal of Inorganic Biochemistry·I G DenisovS G Sligar
Feb 15, 2008·Journal of the American Chemical Society·Chuanjiang HuW Robert Scheidt
Oct 24, 1986·Nucleic Acids Research·G H FangL P Hager
Feb 15, 1985·European Journal of Biochemistry·A M Lambeir, H B Dunford
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·P G DebrunnerL P Hager
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·X YiL P Hager
Sep 22, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Chuanjiang HuW Robert Scheidt
Oct 1, 1979·Environmental Research·G D CaseJ C Schooley
Feb 1, 1983·Archives of Biochemistry and Biophysics·A M Lambeir, H B Dunford
Jun 1, 2002·Applied and Environmental Microbiology·Rosie E BradshawJanet M Seconi
Jul 3, 2007·Applied and Environmental Microbiology·Dau Hung AnhMartin Hofrichter
May 6, 1986·Biochemistry·O BangcharoenpaurpongL P Hager
Oct 27, 2005·Journal of the American Chemical Society·Chuanjiang HuW Robert Scheidt

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