Mossy fibre sprouting: evidence against a facilitatory role in epileptogenesis

Neuroreport
E ElmérD C McIntyre

Abstract

Sprouting of mossy fibres from dentate granule cells occurs in several animal models of epilepsy and in epileptic humans. Mossy fibre sprouting might contribute to epileptogenesis but also could be a compensatory, inhibitory response. We analysed mossy fibre sprouting in the supragranular zone of the dentate gyrus using Timm's histochemical method in genetically fast and slow kindling rats. Before the start of amygdala kindling, the slow rats showed higher Timm's staining scores than did the fast kindlers. No increase of mossy fibre density was observed when the animals were stimulated until either the fast or the slow rats had reached the fully kindled state. Our data argue against the hypothesis that mossy fibre sprouting facilitates epileptogenesis.

Citations

Oct 12, 2000·Annals of Neurology·R SankarC G Wasterlain
Mar 12, 2002·The European Journal of Neuroscience·Sari LähteinenEero Castrén
Jul 17, 2009·Journal of Neurotrauma·Viviane BouilleretTerence J O'Brien
May 17, 2017·Epilepsy & Behavior : E&B·Norberto Garcia-CairascoJosé A Cortes de Oliveira
Jan 19, 2017·Reviews in the Neurosciences·Mojdeh NavidhamidiNasrin Mehranfard
Dec 18, 2018·Frontiers in Neurology·Clarissa F CavarsanLuciene Covolan

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