Most children with eosinophilic esophagitis have a favorable outcome as young adults

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
M BohmJ M Wo

Abstract

The disease progression of eosinophilic esophagitis (EoE) from childhood into adulthood is unclear. To determine the clinical outcome of patients who were diagnosed with EoE as children, and who now are young adults. Children (<18 years old) diagnosed with EoE were enrolled in a prospective registry on demographics, presenting symptoms, and endoscopic/histologic findings. Subjects who now are adults (≥18 years old) were identified, and a structured telephone interview was conducted to obtain follow-up data on symptom prevalence (dysphagia to solids and liquids, nausea/vomiting, abdominal pain, and heartburn/regurgitation), food impaction, medication usage, health-care utilization, and resolution of atopy/food allergies. A favorable outcome was defined if EoE symptoms were resolved or improved by subjects' assessment. Unfavorable outcomes was defined as symptoms same or worse. Clinical variables that predicted a favorable outcome as an adult were examined. Mayo Dysphagia Scale (MDQ-30: scored 0-100) was administered to validate the outcome assessment. Mantel-Haenszel odds ratio and unpaired t-test were used. Fifty-eight subjects (64% male) who met study criteria were enrolled. Mean age at diagnosis was 12 years (range 4-17) and ...Continue Reading

References

Feb 8, 2005·The Journal of Allergy and Clinical Immunology·Alex Straumann, Hans-Uwe Simon
Jun 14, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael CamilleriDennis A Revicki
Dec 20, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Chris A LiacourasJonathan E Markowitz
May 19, 2007·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·A B M GrudellY Romero
Jan 28, 2009·Journal of Pediatric Gastroenterology and Nutrition·Jonathan M SpergelChris A Liacouras
May 23, 2009·American Journal of Clinical Pathology·Christa Lynn Whitney-MillerEmma Elizabeth Furth
Jul 7, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ganapathy A PrasadNicholas J Talley
Sep 8, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Evan S DellonNicholas J Shaheen
Jun 4, 2011·The Journal of Allergy and Clinical Immunology·Charles W DeBrosseMarc E Rothenberg
Oct 25, 2011·The Journal of Allergy and Clinical Immunology·Petr HruzUNKNOWN Swiss EoE study group
Apr 6, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jeffrey A AlexanderNicholas J Talley
Jun 26, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Evan S Dellon
Nov 6, 2012·Alimentary Pharmacology & Therapeutics·P Menard-KatcherG W Falk
Nov 22, 2012·Expert Review of Clinical Immunology·Alfredo J Lucendo, Marta Sánchez-Cazalilla
Apr 10, 2013·The American Journal of Gastroenterology·Evan S DellonUNKNOWN American College of Gastroenterology

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Citations

Nov 8, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Rosan MeyerNeil Shah
Jan 6, 2017·Journal of Pediatric Gastroenterology and Nutrition·Calies Menard-KatcherRobert E Kramer
Oct 5, 2019·Current Pediatric Reviews·Arianna De MatteisGiovanni Di Nardo

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