PMID: 7086102Apr 1, 1982Paper

Most patients with active symptomatic duodenal ulcers fail to develop ulcer-type pain in response to gastroduodenal acidification

Journal of Clinical Gastroenterology
A HarrisonL Hagie


The most frequent symptom of duodenal ulcer is epigastric pain. However, the pathogenesis of duodenal ulcer pain is not established, although it is often attributed to duodenal acidification. The purpose of this study was to determine whether or not gastroduodenal acidification with either 400 ml of pH 1 citric acid or pH 0.85 hydrochloric acid resulted in ulcer-type pain in patients with endoscopically documented active symptomatic duodenal ulcer under doubled-blind randomized conditions. Thirteen consecutive male duodenal ulcer patients with daytime and nocturnal epigastric pain were studied before beginning medical therapy; five with citric acid or sodium citrate at pH's 1, 3, and 7, and eight with hydrochloric acid at pH 0.85 and pH 7 sodium citrate. Ten normal subjects served as controls. Four of the five symptomatic duodenal ulcer patients failed to have pain with the pH 1 citric acid, while one developed pain. Five of the eight patients tested with 0.15 mM hydrochloric acid had no pain. Of the three who developed pain with hydrochloric acid, two had endoscopic evidence of esophagitis (one developed retrosternal pain and one both retrosternal and epigastric pain), and one had the sensation of epigastric "fullness" with bo...Continue Reading


Jul 1, 1988·Baillière's Clinical Gastroenterology·S K Lam
Jan 16, 1999·Baillière's Clinical Gastroenterology·K E McColl
Mar 1, 1987·Scandinavian Journal of Gastroenterology·R Jorde, P G Burhol
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·E C TEXTER
Jan 1, 1985·Scandinavian Journal of Gastroenterology·P M KlevelandH Petersen

Related Concepts

Double-Blind Method
Duodenal Ulcer
Hydrogen Chloride
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