Most patients with HCV-associated lymphoma present with mild liver disease: a call to revise antiviral treatment prioritization

Liver International : Official Journal of the International Association for the Study of the Liver
Harrys A Torres, Parag Mahale

Abstract

Hepatitis C virus (HCV) is associated with development of B-cell non-Hodgkin lymphoma (HCV-NHL). Antiviral therapy (AVT) is prioritized in HCV-infected patients with significant fibrosis/cirrhosis. It is unknown whether current recommendations based on liver parameters cover the risk of HCV-NHL development. We aimed to evaluate the liver disease stages of patients with HCV-NHL. Hepatitis C virus-NHL patients seen at MD Anderson Cancer Center between 2008 and 2014 were evaluated for underlying liver disease within a year of HCV-NHL diagnosis by non-invasive fibrosis markers, radiology or liver biopsy. Included patients were observed retrospectively (2008-2012) or prospectively (2012-2014). Eighty nine patients with HCV-NHL were evaluated. Most patients had genotype 1 (62%) infection, had diffuse large B cell lymphomas (62%), and detectable HCV RNA (90%) at NHL diagnosis. Notably, advanced liver disease (Metavir stage ≥ 3) was present in only 18% of the patients at the time of HCV-NHL diagnosis. All 53 patients with chronic HCV infection documented before lymphoma diagnosis were seen by HCV-treating physicians. Providers did not recommend AVT in almost one half of cases (44%), mostly because of the lack of advanced liver disease ...Continue Reading

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Citations

Aug 9, 2016·International Journal of Cancer. Journal International Du Cancer·Jeff HosryHarrys A Torres
Jul 23, 2016·Blood·Harrys A Torres, George B McDonald
Nov 4, 2017·Infection·Massimo AndreoniAntonio Craxì
Feb 23, 2020·Immunology and Cell Biology·Clara Young, Robert Brink
Dec 17, 2017·Annals of Hematology·Xiang ZhouMathias Witzens-Harig
Sep 21, 2018·American Society of Clinical Oncology Educational Book·Lung-Yi MakJessica P Hwang
Jul 29, 2016·World Journal of Gastroenterology : WJG·Romeo-Gabriel Mihăilă
Oct 13, 2018·World Journal of Hepatology·Issam I RaadRay Hachem

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