Abstract
Primary central nervous system lymphomas are rare neoplasms characterized by a dismal prognosis relative to other extranodal lymphomas. Approximately 98% of primary central nervous system lymphomas are of B-cell origin, and most belong to the diffuse large B-cell type. Recently, diffuse large B-cell lymphomas have been subcategorized into germinal center and nongerminal center types based on gene expression profiles and immunohistochemical expression of CD10, Bcl-6, and MUM1. Studies have shown that the overall survival rate of the germinal center group is better than that of the nongerminal center lymphomas. In this study, 31 cases of primary central nervous system lymphomas of the diffuse large B-cell type were retrieved, reviewed, and immunostained for CD10, Bcl-6, MUM1, and Ki-67. Subclassification was carried out as described earlier, where CD10 and/or Bcl-6 positivity and negativity for MUM1 were considered characteristic of germinal center subtype and the opposite expression of nongerminal center subtype. Furthermore, the proliferative activity was semiquantitatively assessed using percent positive cells staining with Ki-67. Of the 31 cases examined, 26 (84%) were found to belong to the nongerminal center type. The Ki-67...Continue Reading
References
Aug 15, 1994·Cancer·D C MillerH Cohen
Mar 15, 1994·Cancer·M C Chamberlain
May 15, 1996·Journal of the National Cancer Institute·T R CotéP Hartge
Apr 18, 1998·Brain Pathology·J M CobbersG Reifenberger
May 26, 1998·Acta Neuropathologica·M NozakiH Abe
Feb 17, 2000·Nature·A A AlizadehL M Staudt
Mar 21, 2002·Surgical Neurology·Manish PowariA K Banerjee
Jun 21, 2002·The New England Journal of Medicine·Andreas RosenwaldUNKNOWN Lymphoma/Leukemia Molecular Profiling Project
Jan 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrés J M FerreriFranco Cavalli
Feb 4, 2003·Archives of Pathology & Laboratory Medicine·Chung-Che ChangSherrie L Perkins
Sep 25, 2003·Blood·Christine P HansWing C Chan
Oct 3, 2003·Leukemia·A KrämerG Ott
Apr 17, 2004·The American Journal of Surgical Pathology·Chung-Che ChangSherrie L Perkins
May 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Eric M BessellJosep Petit
Oct 20, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sayaka YoshidaMasafumi Abe
May 21, 2005·Blood·Christian HoffmannHeinz-August Horst
May 28, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mattias BerglundGunilla Enblad
Sep 10, 2005·Blood·Sophie Camilleri-BroëtAntoine Martin
Jan 19, 2006·Blood·James L RubensteinMarc Shuman
Feb 21, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ching-Hung LinAnn-Lii Cheng
Sep 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gustaaf W van ImhoffPhilip M Kluin
Sep 26, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mousa A Al-AbbadiThomas M Ulbright
Apr 11, 2008·Bulletin of Experimental Biology and Medicine·A V GrafE N Goncharenko
Jul 23, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francois M CadyEllen D Remstein
Nov 4, 2008·Archives of Pathology & Laboratory Medicine·Sharathkumar Bhagavathi, Jon D Wilson
Citations
Jun 10, 2010·Head and Neck Pathology·Indraneel BhattacharyyaSamer Z Al-Quran
Dec 14, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Sarah E MartinEyas M Hattab
Aug 23, 2012·PloS One·Steen H Matthiesen, Charles M Hansen
Mar 8, 2013·PloS One·Hiroko TodaTadashi Yoshino
Oct 28, 2014·Leukemia & Lymphoma·So YamadaKazuto Yamazaki
May 28, 2014·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Chris OrFarzin Forooghian
Oct 27, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Xinmin ZhangJian Yi Li
May 27, 2015·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Gustavo TapiaJose-Luis Mate
Mar 10, 2015·Neurology India·Bimal PatelMazda Turel
Dec 6, 2014·PloS One·Kamraan Z GillGovind Bhagat
Jun 12, 2016·BMC Cancer·Sehui KimYoon Kyung Jeon
Aug 12, 2015·American Journal of Hematology·Tarec Christoffer El-GalalyMartin Hutchings
Nov 4, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Shuangping GuoZhe Wang
Aug 5, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Uiju ChoYoun Soo Lee
Jul 24, 2018·Leukemia & Lymphoma·Prakash AmbadyEdward A Neuwelt
Oct 9, 2019·Current Opinion in Neurology·K Grace Ho, Christian Grommes
Apr 9, 2020·Blood Advances·Nabila BelhouachiFrederic Davi
Jun 20, 2012·Cancer Control : Journal of the Moffitt Cancer Center·Anamarija M PerryWing C Chan
Oct 1, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Seung-Myoung SonYoung-Hyeh Ko
May 7, 2010·Journal of Neuro-oncology·Neerja VajpayeeAjeet Gajra
Jul 4, 2018·Journal of Neuro-oncology·Keishi MakinoAkitake Mukasa
Oct 19, 2017·Journal of Neuropathology and Experimental Neurology·Qian-Yun ShiQun-Li Shi
Feb 7, 2018·South Asian Journal of Cancer·A H RudreshaL K Rajeev
Dec 20, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Chelsea MarcusHemant Varma
Jan 29, 2021·Frontiers in Molecular Biosciences·Wei Jian TanTong Seng Lim
Dec 17, 2020·Diagnostics·Marietya I S LauwKwun Wah Wen
Dec 29, 2020·Surgical Neurology International·Bishan Dass RadotraSunil Kumar Gupta
Sep 6, 2020·Annals of Diagnostic Pathology·Sergio Pina-OviedoMurat Gokden
Aug 3, 2021·Clinical Neurology and Neurosurgery·Le GeHua Yan
Aug 21, 2018·Analytical Chemistry·Nadya OstromohovGovind V Kaigala
Dec 5, 2021·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Mayur ParkhiBishan Dass Radotra