PMID: 12421257Nov 8, 2002

Most reliable indices in differentiation between thalassemia trait and iron deficiency anemia

Pediatrics International : Official Journal of the Japan Pediatric Society
Aysin DemirAbdurrahman Kara

Abstract

Iron deficiency anemia (IDA) and thalassemia trait (TT) are the most common forms of microcytic anemia. Some discrimination indices calculated from red blood cell indices are defined and used for rapid discrimination between TT and IDA. However, there has been no study carried out in which the validity of all of the defined indices are compared in the same patient groups. Youden's index is the most reliable method by which to measure the validity of a particular technique, because it takes into account both sensitivity and specificity. We calculated eight discrimination indices (Mentzer Index, England and Fraser Index, Srivastava Index, Green and King Index, Shine and Lal Index, red blood cell (RBC) count, red blood cell distribution width and red blood cell blood distribution width index (RDWI)) in 26 patients with IDA and in 37 patients with beta TT (betaTT). We determined the number of correctly identified patients by using each discrimination index. We also calculated sensitivity, specificity, positive and negative predictive value and Youden's index of each discrimination index. None of the discrimination indices showed a sensitivity and specificity of 100%. Youden's indices of RBC count and RDWI were the highest with the ...Continue Reading

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Related Concepts

Teens
Differential Diagnosis
Red Blood Cell Count Measurement
Mean Corpuscular Hemoglobin Concentration Determination
Isoferritin
Hemoglobin A2
Iron
Statistical Sensitivity
Viral Markers
Thalassemia Minor

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