Most sleep does not serve a vital function: Evidence from Drosophila melanogaster

Science Advances
Quentin GeissmannGiorgio F Gilestro

Abstract

Sleep appears to be a universally conserved phenomenon among the animal kingdom, but whether this notable evolutionary conservation underlies a basic vital function is still an open question. Using a machine learning-based video-tracking technology, we conducted a detailed high-throughput analysis of sleep in the fruit fly Drosophila melanogaster, coupled with a lifelong chronic and specific sleep restriction. Our results show that some wild-type flies are virtually sleepless in baseline conditions and that complete, forced sleep restriction is not necessarily a lethal treatment in wild-type D. melanogaster. We also show that circadian drive, and not homeostatic regulation, is the main contributor to sleep pressure in flies. These results offer a new perspective on the biological role of sleep in Drosophila and, potentially, in other species.

References

Feb 13, 1992·The New England Journal of Medicine·R MedoriP Cortelli
Jul 1, 1966·Archives of General Psychiatry·G GulevichL Johnson
Feb 24, 1967·Science·L S Ewing
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·S S Campbell, I Tobler
Jul 8, 1983·Science·A RechtschaffenJ B Winter
Jun 1, 1983·Behavioural Brain Research·I Tobler
Jul 1, 1995·Behavioural Brain Research·I Tobler
Jul 1, 1995·Behavioural Brain Research·A Rechtschaffen, B M Bergmann
Aug 3, 1995·Nature·J TateishiD C Gajdusek
Apr 1, 1996·Trends in Microbiology·A Aguzzi, C Weissmann
Mar 1, 1996·Journal of Sleep Research·I Tobler, B Schwierin
Jul 1, 1997·Sleep·M Bentivoglio, G Grassi-Zucconi
Jul 22, 1998·Brain Research Bulletin·J L Kavanau
Sep 25, 2003·Cellular and Molecular Life Sciences : CMLS·E Kubli
Jul 15, 2004·PLoS Biology·Niels C RattenborgRuth M Benca
Apr 5, 2007·Nature Protocols·Ezio Rosato, Charalambos P Kyriacou
May 8, 2007·Sleep Medicine Reviews·Ruben Victor RialSusana Esteban
Jun 15, 2007·Sleep Medicine Reviews·Niels C RattenborgSteven L Lima
Sep 4, 2007·Physiology & Behavior·Sarah M NewmanRuth M Benca
Aug 30, 2008·PLoS Biology·Chiara Cirelli, Giulio Tononi
Nov 8, 2008·Biology Letters·T FuchsV P Bingman
Nov 19, 2008·Sleep·John E ZimmermanAllan I Pack
Aug 1, 2009·Neuroscience and Biobehavioral Reviews·Jim Horne
Aug 6, 2009·Nature Reviews. Neuroscience·Jerome M Siegel
May 18, 2010·Current Biology : CB·Carlos Ribeiro, Barry J Dickson
Dec 27, 2011·Neuron·Nicholas Stavropoulos, Michael W Young
Jan 13, 2012·Journal of Neurogenetics·Kaoru MasuyamaJing W Wang
Mar 7, 2012·Ecology and Evolution·Therese Ann Markow
Apr 28, 2012·Nature Protocols·Giorgio F Gilestro
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Apr 27, 2013·BMC Genomics·Susan T HarbisonTrudy F C Mackay
Dec 18, 2013·PLoS Biology·Esteban J BeckwithMaría Fernanda Ceriani
Nov 1, 2015·Biology Open·David S GarbeAlex C Keene
May 25, 2016·Current Biology : CB·Till Roenneberg, Martha Merrow
Sep 24, 2016·Journal of Biological Rhythms·David S GarbeAmita Sehgal
Oct 25, 2016·ELife·Verónica María Corrales-CarvajalCarlos Ribeiro
Aug 31, 2017·Physiology & Behavior·Abigail E DoveChristopher G Vecsey

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Citations

May 16, 2019·Proceedings of the National Academy of Sciences of the United States of America·Alexander Varshavsky
Apr 11, 2020·F1000Research·Maxime JanPaul Franken
Oct 2, 2019·Frontiers in Physiology·Esteban J Beckwith, Alice S French
Apr 19, 2020·Proceedings of the National Academy of Sciences of the United States of America·Timothy D WigginLeslie C Griffith
May 1, 2020·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Suzanne E McGaughAlex C Keene
Jan 13, 2021·Current Biology : CB·Orie T Shafer, Alex C Keene
Sep 22, 2020·Trends in Parasitology·Oluwaseun M AjayiJoshua B Benoit
Feb 20, 2021·Neurobiology of Sleep and Circadian Rhythms·Marcos G Frank
Apr 27, 2021·Frontiers in Neuroscience·Yuri Panchin, Vladimir M Kovalzon
May 2, 2021·Scientific Reports·Fuminori Tanizawa, Hiroyuki Takemoto
Oct 1, 2021·Nature·Alice S FrenchGiorgio F Gilestro
Dec 16, 2021·The FEBS Journal·José Manuel DuhartKyunghee Koh

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Methods Mentioned

BETA
transgenic
Light Microscopy

Software Mentioned

R
CaLexA
Drosophila Activity Monitor ( vDAM )
ZENODO
ggplot2

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