Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology.

The Journal of Heredity
M C Green, L Shultz

Abstract

A new recessive mutation, motheaten (me), is on chromosome 6, 21.9 +/- 4.3 recombination units distal to white (Miwh). Mice homozygous for the new mutation have neutrophilic lesions of the skin beginning as early as day 1, and pneumonitis with many macrophages in the alveoli as early as day 3. They suffer high mortality from birth onward and none has survived longer than 8 weeks. The lymph nodes may be enlarged, but the thymus, Reyer's patches, and lymphatic tissue of the spleen are much reduced in size. Lymph nodes, spleen, and Peyer's patches lack lymphatic nodules. The lymph nodes and spleen contain many plasma cells. There are increased numbers of neutrophils and monocytes in the peripheral blood, and increased numbers of neutrophils in bone marrow at the expense of red cell precursors. Hematopoietic tissue in the spleen is increased and appears more active than normal. Motheaten mice appear to have an immune deficiency beginning very shortly after birth.

Citations

Mar 1, 1978·Veterinary Pathology·J M Ward
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·R W Elliott, K J Moore
Jul 1, 1991·The American Journal of Anatomy·L D Shultz
Jan 1, 1997·Annual Review of Immunology·A FischerF Le Deist
May 20, 2014·Seminars in Immunopathology·John R Lukens, Thirumala-Devi Kanneganti
Jul 24, 2014·Rare Diseases·John R Lukens, Thirumala-Devi Kanneganti
Jun 30, 2016·European Journal of Immunology·Ryan J MartinezBrian D Evavold
Jun 14, 2017·Journal of Leukocyte Biology·Clare L Abram, Clifford A Lowell
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keke FanTaolin Yi
Feb 27, 2003·Immunology·Nicholas R Pritchard, Kenneth G C Smith
Nov 11, 2003·The Journal of Biological Chemistry·Samuel Wormald, Douglas J Hilton
Oct 28, 2008·American Journal of Respiratory Cell and Molecular Biology·Sun Young OhZhou Zhu
Jan 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Li ZhangZhou Zhu
Mar 18, 2009·Immunological Reviews·Ulrike Lorenz
Sep 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ben A CrokerBruce Alan Beutler
Nov 12, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Joseph J SabatinoBrian D Evavold
Apr 29, 2008·American Journal of Respiratory Cell and Molecular Biology·You Sook ChoZhou Zhu
Dec 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ben A CrokerAndrew W Roberts
Apr 6, 2011·Journal of Cellular Biochemistry·Wei WangG Wayne Zhou
May 28, 2013·Nature·John R LukensThirumala-Devi Kanneganti
Apr 6, 2013·Neuroscience Bulletin·Jared T Ahrendsen, Wendy Macklin
Feb 15, 2013·Genetic Testing and Molecular Biomarkers·Dorra BouzidHatem Masmoudi
Apr 14, 2016·Biochemical Society Transactions·H Angharad WatsonAnn Ager
May 1, 1990·European Journal of Immunology·A A Freitas, C L Sidman
May 10, 2001·International Journal of Hematology·B T KileW S Alexander
Dec 1, 1986·Immunological Reviews·C PainterC A Bona
Apr 28, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tetsuya KanekoTakashi Matozaki
Feb 22, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna NapolitanoGiulia Casorati
May 4, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Caroline LeblancNathalie Rivard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.