PMID: 9430166Jan 16, 1998Paper

Mother-child HIV-1 transmission: Timing and determinants

Obstetrics and Gynecology Clinics of North America
L Mofenson

Abstract

Prevention of mother-to-child transmission of HIV is a significant public health priority. A regimen of zidovudine administered during pregnancy, intrapartum, and to the newborn significantly reduces transmission, and incorporation of this regimen into clinical practice has been associated with significant decreases in perinatal transmission in industrialized countries. This regimen, however, is not applicable in the developing world (where most perinatal transmission occurs), and simpler, shorter, less costly regimens are urgently needed. An understanding of the pathogenesis of perinatal transmission is crucial for the design of new preventive and therapeutic regimens, and current knowledge is reviewed in this article, with an emphasis on relevance to prevention.

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Citations

Jan 11, 2002·Journal of Midwifery & Women's Health·L Patchen, M W Beal
Aug 8, 2002·Oral Diseases·Gillian M McCarthyK Page-Shafer
Apr 1, 1999·The New England Journal of Medicine·UNKNOWN International Perinatal HIV GroupR Tuomala
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May 5, 2007·BMJ : British Medical Journal·Glenda E Gray, James A McIntyre
Jan 1, 2010·Journal of Leukocyte Biology·K García-CrespoL M Meléndez
Nov 13, 2014·Expert Opinion on Drug Safety·Marilia Santini-Oliveira, Beatriz Grinsztejn
Aug 25, 2004·Anesthesiology Clinics of North America·Samuel C Hughes
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Aug 17, 2021·Comparative Immunology, Microbiology and Infectious Diseases·Juscilânia Furtado AraújoMaria Fátima da Silva Teixeira

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