PMID: 8938534Nov 1, 1996Paper

Mother-to-child transmission of a hepatitis C virus variant with an insertional mutation in its hypervariable region

Journal of Hepatology
H AizakiT Miyamura

Abstract

We have analyzed the molecular basis of mother-to-child transmission of hepatitis C virus. Healthy pregnant women were screened for anti-HCV antibody and babies born to hepatitis C virus carrier mothers were prospectively investigated. Among the 35 pairs studied, the hepatitis C virus genome was detectable in only one baby, who did not show any significant symptoms of hepatitis. The viral load in the blood of the mother was one of the highest of the 35, and the population of the hepatitis C virus genome was heterogeneous. Furthermore, she was found to have a mixed infection with type 1a and type 1b hepatitis C virus. However, the hepatitis C virus genome obtained from the baby was only from type 1b, less heterogeneous and composed of the clones which were detected in the blood of the mother. The selected hepatitis C virus had a 12-nucleotide insertion in the amino-terminus of the E2 hypervariable region of the genome. The incidence of mother-to-child transmission of hepatitis C virus from carrier mothers was shown by this prospective study to be low. The presence of selection pressure during transmission was suggested. The biological significance of the virus with 12-nucleotide insertion has to be determined.

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Citations

Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H AizakiT Miyamura
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K IshiiT Miyamura
Mar 6, 2002·Journal of Viral Hepatitis·M I Memon, M A Memon
Jun 27, 2002·Journal of Gastroenterology and Hepatology·Ayano InuiIsao Sekine
Feb 7, 2001·Clinical Microbiology Reviews·N N Zein
Sep 14, 2012·The Journal of General Virology·Brendan A PalmerLiam J Fanning
Apr 21, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Rudrapathy ParthibanSadras Panchatcharam Thyagarajan

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