PMID: 7540080Mar 1, 1995Paper

Mother-to-infant transmission of hepatitis C virus

Acta Paediatrica
M RestiA Vierucci

Abstract

Anti-hepatitis C virus (HCV) antibodies and HCV-RNA were measured in the sera of 22 anti-HCV positive, HIV-1 negative mothers and their infants. ELISA and RIBA II were used for anti-HCV determination. HCV-RNA was measured by a nested polymerase chain reaction. HCV-RNA was found in 12 of 22 mothers. All 22 children were followed for 12 months. All were anti-HCV positive by the fourth month; 18 became anti-HCV negative between the 8th and 12th month. HCV-RNA was detected in 5 of 22 infants in the fourth month. They remained HCV-RNA positive. All children born to HCV-RNA negative mothers were HCV-RNA negative while 5 of 12 babies born to HCV-RNA positive mothers were infected. All five infected babies were born to mothers infected through transfusions or drug use. ALT levels in mothers seemed to have no effect on mother-to-infant transmission. Hence evidence for perinatal transmission of HCV from HCV-RNA positive mothers was demonstrated in the present study.

References

May 1, 1992·PCR Methods and Applications·A RavaggiE Cariani
Mar 1, 1992·The Journal of Pediatrics·I NagataT Okada
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T A ChaM S Urdea
Dec 1, 1992·Annals of Internal Medicine·J F ReinusJ W Shih
Dec 1, 1992·Annals of Internal Medicine·R WejstålG Norkrans
Jul 11, 1991·The New England Journal of Medicine·P FarciR H Purcell
Aug 1, 1991·The Journal of Infectious Diseases·T KurokiK Kobayashi
Sep 1, 1991·Gut·S Sherlock, G Dusheiko
Oct 17, 1991·Nature·Y InoueI Saito
Dec 1, 1991·The Journal of Pediatrics·P S WeintrubM M Thaler
Jul 6, 1991·Lancet·M M ThalerJ H Han
May 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R GoldinH Thomas
May 18, 1989·Nature·S Kwok, R Higuchi
Mar 1, 1993·The Journal of Infectious Diseases·J P LamP Simmonds
Jul 1, 1993·The Journal of Pediatrics·C CamareroM Mateos

❮ Previous
Next ❯

Citations

Dec 24, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S L ThomasA J Hall
May 1, 1997·Obstetrics and Gynecology·C M HuntA I Sharara
Jan 6, 2000·Journal of Hepatology·M Ruiz-MorenoA Millàn
Jan 6, 2000·Journal of Hepatology·D Lavanchy
Mar 1, 1997·Infectious Disease Clinics of North America·M J Dinsmoor
May 22, 2001·AIDS Patient Care and STDs·C A Sabin
May 19, 2000·Journal of Pediatric Gastroenterology and Nutrition·M RestiA Vierucci
Feb 15, 2001·The Pediatric Infectious Disease Journal·H TajiriS Okada
Aug 6, 2003·Plastic and Reconstructive Surgery·Robert A YohoAndrea T Cruz
Apr 28, 2004·Southern Medical Journal·Brian L Pearlman
Nov 1, 1996·Archives of Disease in Childhood·D A Kelly
Nov 16, 2004·Arquivos De Gastroenterologia·Mário Ferreira PeixotoAna Maria Ponzio de Azevedo
Jan 1, 1996·Scandinavian Journal of Infectious Diseases·B FischlerA Nemeth
Mar 26, 2009·Journal of Medical Virology·Giuseppe Indolfi, Massimo Resti
Oct 24, 2003·The Journal of the Association of Nurses in AIDS Care : JANAC·Jacqueline Rhoads
Mar 20, 1998·Annals of Emergency Medicine·T A Morton, G D Kelen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.