Mother's nutritional miRNA legacy: Nutrition during pregnancy and its possible implications to develop cardiometabolic disease in later life

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Patricia Casas-AgustenchAlberto Dávalos

Abstract

Maternal nutrition during pregnancy and lactation influences the offspring's health in the long-term. Indeed, human epidemiological studies and animal model experiments suggest that either an excess or a deficit in maternal nutrition influence offspring development and susceptibility to metabolic disorders. Different epigenetic mechanisms may explain in part the way by which dietary factors in early critical developmental steps might be able to affect the susceptibility to develop metabolic diseases in adulthood. microRNAs are versatile regulators of gene expression and play a major role during tissue homeostasis and disease. Dietary factors have also been shown to modify microRNA expression. However, the role of microRNAs in fetal programming remains largely unstudied. This review evaluates in vivo studies conducted to analyze the effect of maternal diet on the modulation of the microRNA expression in the offspring and their influence to develop metabolic and cardiovascular disease in later life. In overall, the available evidence suggests that nutritional status during pregnancy influence offspring susceptibility to the development of cardiometabolic risk factors, partly through microRNA action. Thus, therapeutic modulation o...Continue Reading

References

Feb 15, 2001·International Journal of Epidemiology·J E Harding
Nov 20, 2001·EMBO Reports·J S Mattick
Nov 1, 2005·Nature·Jan KrützfeldtMarkus Stoffel
Feb 7, 2006·Cell Metabolism·Christine EsauBrett P Monia
Jan 27, 2007·Circulation Research·Irina BogdarinaAdrian J L Clark
Mar 17, 2007·Nature Reviews. Genetics·Randy L Jirtle, Michael K Skinner
Jul 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Peter D GluckmanMark A Hanson
Nov 24, 2007·Mechanisms of Ageing and Development·Piran ShelleyJosie McConnell
Jan 30, 2009·Journal of Anatomy·Simon C Langley-Evans
Feb 4, 2010·Journal of Lipid Research·Dimitrios IliopoulosVassilis I Zannis
Feb 25, 2010·Heredity·V Bollati, A Baccarelli
Nov 30, 2010·The Proceedings of the Nutrition Society·Rebecca Simmons
Mar 23, 2011·Birth Defects Research. Part C, Embryo Today : Reviews·Peter D GluckmanFelicia M Low
Apr 6, 2011·Current Opinion in Cardiology·Mingyue HanMaha Abdellatif
May 12, 2011·FEBS Letters·John S Mattick
Oct 20, 2011·Nutrition Research Reviews·Roberto Berni CananiCarlo Agostoni
Jan 24, 2012·Cardiovascular Research·Paula A Da Costa Martins, Leon J De Windt
Mar 20, 2012·Cell·Joshua T Mendell, Eric N Olson
Mar 27, 2012·The Journal of Nutritional Biochemistry·Rihua CongRuqian Zhao
May 23, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·X YanM Du
Sep 18, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·L M Berends, S E Ozanne
Dec 21, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Fatima L C SardinhaEmilio Herrera
Jan 15, 2013·Pediatric Research·Silvia SookoianCarlos J Pirola
Mar 29, 2013·The New England Journal of Medicine·Harry L A JanssenMichael R Hodges
May 23, 2013·Physiological Genomics·Pao-Yang ChenMatteo Pellegrini
Jul 6, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Alberto Dávalos, Yajaira Suárez
Apr 15, 2014·Nature Neuroscience·Katharina GappIsabelle M Mansuy
Apr 30, 2014·Nature Reviews. Genetics·Kevin V Morris, John S Mattick
May 3, 2014·Journal of Toxicologic Pathology·Satoshi FurukawaAkihiko Sugiyama

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Citations

Apr 14, 2016·Current Opinion in Lipidology·Martin P BogsrudKirsten B Holven
Mar 26, 2019·Annual Review of Food Science and Technology·Grace J AhernCatherine Stanton
Aug 7, 2017·Current Hypertension Reports·Andrew C TiuVan Anthony M Villar
Jun 6, 2019·American Journal of Physiology. Cell Physiology·Meng LiYong-Liang Zhang
Feb 19, 2016·Physiological Reviews·Jude S MortonSandra T Davidge
Jun 16, 2019·Nutrients·Diana C Mantilla-EscalanteAlberto Dávalos

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