PMID: 7035374Jan 1, 1982Paper

Mothers of infants with neonatal group B streptococcal septicemia are poor responders to bacterial carbohydrate antigens

International Archives of Allergy and Applied Immunology
K K ChristensenV Lindén

Abstract

Serum antibodies against various carbohydrate antigens were studied in 16 mothers of infants with serious infections caused by group B streptococci (GBS) (the study group), and compared with a control group of 29 urogenital carriers of GBS who gave birth to neonatally healthy infants. Using a radioimmunoassay for the determination of antibodies to GBS types Ia, Ib, II and III, it was found that the study group had significantly lower levels of IgG antibodies to each of the 4 GBS types than the control group. The IgG levels against Salmonella BO and DO, Yersinia enterocolitica 03, Francisella tularense and Streptococcus pneumonia types 3, 6, 9, 19 and 23 purified carbohydrate antigens were determined using an ELISA technique. Significantly more individuals in the study group than in the control group had low levels of IgG antibodies against 8 of 9 carbohydrate antigens. No difference was found in IgM levels against 3 of 4 antigens studied, while the study group showed significantly more IgM antibodies against Salmonella DO than the controls. These results indicate that mothers of GBS-infected infants might be poor IgG antibody responders to bacterial carbohydrate antigens in general.

Citations

May 1, 1994·The Journal of Hospital Infection·F A Orrett, V Olagundoye
Oct 24, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·C LarssonI Krantz
Jul 1, 1990·American Journal of Obstetrics and Gynecology·H M SilverH C Dillon
May 1, 1995·The Australian & New Zealand Journal of Obstetrics & Gynaecology·G L GilbertP McIntyre
Jun 28, 2003·Pediatrics International : Official Journal of the Japan Pediatric Society·Fitzroy A Orrett
Jun 11, 1983·The Medical Journal of Australia·K King

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