Motilin receptor expression in smooth muscle, myenteric plexus, and mucosa of human inflamed and noninflamed intestine

Inflammatory Bowel Diseases
W Pascale Ter BeekCornelis B H W Lamers

Abstract

Besides regulation of upper gastrointestinal motility, motilin seems to play a role in the inflammatory response. Motilin receptor expression in human intestine has not been studied thoroughly. This study aimed to describe the intestinal distribution of motilin receptors in inflammatory bowel disease (IBD) and control patients. Quantitative autoradiography, immunohistochemistry, and reverse-transcriptase polymerase chain reaction (RT-PCR) were used to detect motilin receptors in tissue of 25 IBD patients (13 Crohn's disease [CD], 12 ulcerative colitis [UC]) and 19 patients with a neoplasm (controls). Median muscular motilin binding was 3 and 8 fmol/g tissue in colon and ileum, respectively. In the gastroduodenal region the median was higher (93 fmol/g). In UC colonic muscular motilin binding was significantly increased compared to controls (7 vs. 3 fmol/g, P < or = 0.05). Expression in CD was similar to controls. Besides the binding found in the muscular compartment, motilin binding was also found in the mucosa, which was even higher than in the muscle (3 versus 11 and 8 versus 27 fmol/g for colon and ileum (P < or = 0.06), respectively). RT-PCR and immunohistochemistry confirmed the mucosal motilin receptor expression. The muc...Continue Reading

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Citations

Sep 24, 2015·Nature Reviews. Gastroenterology & Hepatology·Gareth J Sanger, John B Furness
Oct 28, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A MondalT Sakai
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May 12, 2009·Pharmacology & Therapeutics·Betty De SmetInge Depoortere
May 18, 2016·General and Comparative Endocrinology·Auvijit Saha ApuIchiro Sakata
Dec 3, 2014·United European Gastroenterology Journal·Gabrio BassottiMaria Pina Dore
Sep 30, 2009·Current Opinion in Gastroenterology·Eamonn M M Quigley
Jul 21, 2011·American Journal of Physiology. Endocrinology and Metabolism·Pierre MiegueuDavid H St-Pierre
Dec 13, 2012·Advances in Anatomic Pathology·Nunzia BernardiniAmelio Dolfi
Nov 16, 2016·Cell and Tissue Research·Patricia MartinsJohn B Furness
May 27, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jutta KellerPeter Layer
Oct 31, 2017·BioMed Research International·Giuseppe RiezzoFrancesco Russo
Jan 25, 2019·Nature Reviews. Endocrinology·Eveline DelooseJan Tack

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