Motilin

Current Opinion in Endocrinology, Diabetes, and Obesity
P Poitras, T L Peeters

Abstract

Motilin is a hormone produced from endocrine cells of the duodenal mucosa to help regulate motility of the digestive tract. This review discusses new findings on the potential impact of motilin in human medicine. Motilin is a member of the peptide family that includes ghrelin whose cDNA also encodes a new candidate peptide, obestatin. Physiological interactions between these products will have to be explored. Pharmacological agents, agonists as well as antagonists, to motilin receptors are now emerging for clinical application. Motilin-receptor characterization, regarding its localization on nerves or muscles, as well as its biochemical mechanisms to sensitization for example, will be important steps in the design of future motilin agonists or antagonists. Motilin is a fascinating hormone for the physiologist. Its interaction with the family member ghrelin and with obestatin will open new areas for basic research. Motilin-receptor agonists or antagonists could soon be part of the therapeutic arsenal of the clinician to improve digestive dysmotility.

References

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Citations

Jan 9, 2013·Archives of Gynecology and Obstetrics·Ayla Sargın OruçNuri Danışman
Apr 3, 2013·Archives of Gynecology and Obstetrics·Ayla Sargın Oruç
Aug 28, 2010·International Journal of Peptides·Tetsuro OhnoHiroyuki Kuwano
Dec 1, 2009·Future Medicinal Chemistry·Elodie DubusFrançois Petitet
Dec 25, 2009·Journal of Oleo Science·Nagao TotaniHaruyasu Kida
Aug 20, 2010·Journal of Oleo Science·Nagao TotaniHaruyasu Kida
May 23, 2013·Pharmacology & Therapeutics·Stefan AmistenShanta J Persaud
Jul 9, 2010·Regulatory Peptides·Aaron ZietlowToku Takahashi
Sep 29, 2009·European Journal of Internal Medicine·Hillevi PendletonBodil Ohlsson
Nov 6, 2013·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Shaodong ChenLong Li
Mar 19, 2013·General and Comparative Endocrinology·Yun LiuHaoran Lin
May 18, 2016·General and Comparative Endocrinology·Auvijit Saha ApuIchiro Sakata
May 21, 2016·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Emma M TillmanMerrion G Buckley
Nov 16, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Maria DasopoulouAriadne Malamitsi-Puchner
Feb 7, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Kelly A Tappenden
Jul 21, 2011·American Journal of Physiology. Endocrinology and Metabolism·Pierre MiegueuDavid H St-Pierre
Dec 1, 2011·Scandinavian Journal of Gastroenterology·Herbert F Helander, Lars Fändriks
Aug 11, 2011·American Journal of Physiology. Endocrinology and Metabolism·Rolando Ceddia
Jun 17, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jun WanRenquan Zhang

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