Motion-corrected whole-heart PET-MR for the simultaneous visualisation of coronary artery integrity and myocardial viability: an initial clinical validation.

European Journal of Nuclear Medicine and Molecular Imaging
Camila MunozClaudia Prieto

Abstract

Cardiac PET-MR has shown potential for the comprehensive assessment of coronary heart disease. However, image degradation due to physiological motion remains a challenge that could hinder the adoption of this technology in clinical practice. The purpose of this study was to validate a recently proposed respiratory motion-corrected PET-MR framework for the simultaneous visualisation of myocardial viability (18F-FDG PET) and coronary artery anatomy (coronary MR angiography, CMRA) in patients with chronic total occlusion (CTO). A cohort of 14 patients was scanned with the proposed PET-CMRA framework. PET and CMRA images were reconstructed with and without the proposed motion correction approach for comparison purposes. Metrics of image quality including visible vessel length and sharpness were obtained for CMRA for both the right and left anterior descending coronary arteries (RCA, LAD), and relative increase in 18F-FDG PET signal after motion correction for standard 17-segment polar maps was computed. Resulting coronary anatomy by CMRA and myocardial integrity by PET were visually compared against X-ray angiography and conventional Late Gadolinium Enhancement (LGE) MRI, respectively. Motion correction increased CMRA visible vesse...Continue Reading

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Citations

Nov 15, 2018·Physics in Medicine and Biology·Philip M RobsonZahi A Fayad
Feb 15, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Martin Lyngby LassenJacobo Cal-González
Oct 23, 2018·Medicina·Eglė KazakauskaitėRenaldas Jurkevičius
Aug 31, 2018·Cardiology Research and Practice·Azira KhalilKhin Wee Lai
Feb 15, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Reza HajhosseinyRené M Botnar
Jan 22, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Johannes MayerChristoph Kolbitsch
May 11, 2021·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Johannes MayerChristoph Kolbitsch
Jul 6, 2021·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Irene PolycarpouCharalampos Tsoumpas
May 30, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Camila MunozClaudia Prieto

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Methods Mentioned

BETA
X-ray

Software Mentioned

MunichHeart
CMRA
MATLAB

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