Motion-induced sickness following bilateral ablation of area postrema in squirrel monkeys

The Laryngoscope
C R WilpizeskiW Goldman

Abstract

Using squirrel monkeys as experimental subjects, we reexamined the disputed role of the area postrema (AP) in motion-induced vomiting. After anesthetization, the obex and rhomboid fossa were exposed surgically, and the AP was ablated by thermal coagulation using either a battery cautery or a CO2 microsurgical laser. Sham operations were performed on another sample of monkeys. Two or more weeks after surgery, all animals were given 10 daily 2-hour horizontal rotations at 30 rpm. Every monkey in both the lesions and sham samples vomited on two or more test days. While the vomiting characteristics were modified following ablation of AP, its function is not indispensible for the development of motion sickness in horizontally-rotated squirrel monkeys.

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Citations

Sep 26, 2008·Basic & Clinical Pharmacology & Toxicology·Nina L ClunyFarideh A Javid
Aug 13, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yoichiro SugiyamaBill J Yates
Jan 1, 1991·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M A Hamid
Oct 1, 1991·Journal of Clinical Pharmacology·R L Kohl, S MacDonald
Jul 1, 1993·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·T P Murphy
Jan 1, 1993·Acta Oto-laryngologica. Supplementum·N TakedaT Matsunaga
Mar 3, 1999·Brain Research Bulletin·B J YatesJ B Lucot
Jun 6, 2009·Medical Hypotheses·Leonard M Eisenman

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