Motion of Knots in DNA Stretched by Elongational Fields

Physical Review Letters
Alexander R KlotzPatrick S Doyle

Abstract

Knots in DNA occur in biological systems, serve as a model system for polymer entanglement, and affect the efficacy of modern genomics technologies. We study the motion of complex knots in DNA by stretching molecules with a divergent electric field that provides an elongational force. We demonstrate that the motion of knots is nonisotropic and driven towards the closest end of the molecule. We show for the first time experimentally that knots can go from a mobile to a jammed state by varying an applied strain rate, and that this jamming is reversible. We measure the mobility of knots as a function of strain rate, demonstrating the conditions under which knots can be driven towards the ends of the molecule and untied.

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Citations

Dec 8, 2019·Proceedings of the National Academy of Sciences of the United States of America·Alexander R KlotzPatrick S Doyle
Feb 12, 2020·Nucleic Acids Research·Antonio SumaVincenzo Carnevale
Jul 30, 2020·Reports on Progress in Physics·Ivan I Smalyukh
Jan 4, 2020·Science·Vishal P PatilJörn Dunkel
Oct 24, 2019·Physical Review. E·Konstantinos Meichanetzidis, Stefanos Kourtis
Mar 15, 2020·Physical Review. E·Olafs VandansLiang Dai
Dec 18, 2020·Physical Review. E·James M Polson, Cameron G Hastie
Mar 5, 2021·Nano Letters·Rajesh Kumar SharmaSlaven Garaj
Apr 18, 2021·Physical Review. E·Ingrid GendronLuc Capaldi
Mar 26, 2021·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Luca TubianaKostas Daoulas
Mar 12, 2020·The Journal of Physical Chemistry. B·Xiaofei Xu, Xiangxiang Gao
Sep 22, 2021·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Enzo Orlandini, Cristian Micheletti

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