PMID: 8950658Nov 1, 1996Paper

Motion of red blood cells in capillaries with variable cross-sections

Journal of Biomechanical Engineering
T W Secomb, R Hsu

Abstract

Red blood cells undergo continual deformation when traversing microvessels in living tissues. This may contribute to higher resistance to blood flow observed in living microvessels, compared with that in corresponding uniform glass tubes. We use a theoretical model to simulate single-file motion of red cells though capillaries with variable cross-sections, assuming axisymmetric geometry. Effects of cell membrane shear viscosity and elasticity are included, but bending resistance is neglected. Lubrication theory is used to describe the flow of surrounding plasma. When a red cell encounters a region of capillary narrowing, additional energy is dissipated, due to membrane viscosity, and due to narrowing of the lubrication layer, increasing the flow resistance. Predicted resistance to cell motion in a vessel with periodic constrictions (diameter varying between 5 microns and 4 microns) is roughly twice that in a uniform vessel with diameter 4.5 microns. Effects of transient red cell deformations may contribute significantly to blood flow resistance in living microvessels.

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Citations

Nov 26, 2010·Biomechanics and Modeling in Mechanobiology·Fong Yew LeongKeng-Hwee Chiam
Mar 24, 2007·Annals of Biomedical Engineering·Timothy W SecombAxel R Pries
May 19, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Dominik ObristPatrick Jenny
Nov 10, 2001·Annual Review of Biomedical Engineering·G W Schmid-Schönbein
Mar 18, 2005·Annals of Biomedical Engineering·C Pozrikidis
Jan 18, 2011·Annals of Biomedical Engineering·David J QuinnSubra Suresh
Dec 24, 2015·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Gerhard Gompper, Dmitry A Fedosov
Jul 15, 2015·Bulletin of Mathematical Biology·Nathaniel J KarstJohn B Geddes
Oct 25, 2016·Frontiers in Physiology·Tijana R DjukicNenad Filipovic
Dec 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J Vernikos
Sep 24, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Elodie LepaultChristine L Theoret
Aug 23, 2005·American Journal of Veterinary Research·Marilys Ducharme-DesjarlaisChristine L Theoret
Apr 8, 1998·The American Journal of Physiology·T W SecombA R Pries
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·T W SecombA R Pries
Dec 31, 1997·The American Journal of Physiology·A R PriesP Gaehtgens
Sep 26, 2000·American Journal of Physiology. Cell Physiology·R C MurdockR E Waugh
Dec 22, 1999·The American Journal of Physiology·K Parthasarathi, H H Lipowsky

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