Motion Predicts Clinical Callus Formation: Construct-Specific Finite Element Analysis of Supracondylar Femoral Fractures

The Journal of Bone and Joint Surgery. American Volume
Jacob ElkinsWilliam Lack

Abstract

Mechanotransduction is theorized to influence fracture-healing, but optimal fracture-site motion is poorly defined. We hypothesized that three-dimensional (3-D) fracture-site motion as estimated by finite element (FE) analysis would influence callus formation for a clinical series of supracondylar femoral fractures treated with locking-plate fixation. Construct-specific FE modeling simulated 3-D fracture-site motion for sixty-six supracondylar femoral fractures (OTA/AO classification of 33A or 33C) treated at a single institution. Construct stiffness and directional motion through the fracture were investigated to assess the validity of construct stiffness as a surrogate measure of 3-D motion at the fracture site. Callus formation was assessed radiographically for all patients at six, twelve, and twenty-four weeks postoperatively. Univariate and multivariate linear regression analyses examined the effects of longitudinal motion, shear (transverse motion), open fracture, smoking, and diabetes on callus formation. Construct types were compared to determine whether their 3-D motion profile was associated with callus formation. Shear disproportionately increased relative to longitudinal motion with increasing bridge span, which was...Continue Reading

References

Aug 1, 1986·Journal of Biomechanical Engineering·A M DiGioiaW C Hayes
Aug 1, 1985·The Journal of Bone and Joint Surgery. British Volume·A E Goodship, J Kenwright
Jan 26, 1999·Clinical Orthopaedics and Related Research·L E ClaesP Augat
Jan 10, 2002·Clinical Biomechanics·Georg N DudaNorbert P Haas
Jan 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·E G LoboaD R Carter
Feb 23, 2002·Clinical Orthopaedics and Related Research·Georg N DudaMichael Raschke
May 15, 2003·Computer Methods in Biomechanics and Biomedical Engineering·D Lacroix, P J Prendergast
Oct 14, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Peter AugatLutz Claes
Oct 29, 2003·Injury·Christoph SommerMichael Wagner
Aug 5, 2004·Clinical Orthopaedics and Related Research·David RingJesse B Jupiter
Oct 12, 2004·Journal of Orthopaedic Trauma·Kenneth A EgolKenneth J Koval
Oct 12, 2004·Journal of Orthopaedic Trauma·Gavin ButtonDavid Hak
Mar 29, 2006·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hans K UhthoffDavid S Backman
Dec 5, 2006·The Journal of Bone and Joint Surgery. American Volume·Erik N KubiakKenneth A Egol
Jan 8, 2008·Journal of Orthopaedic Trauma·Peter AugatVolker Bühren
Jan 22, 2009·Biomechanics and Modeling in Mechanobiology·Lauren Nicole Miller Hayward, Elise F Morgan
Feb 27, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kristy T Salisbury PalomaresElise F Morgan
Nov 17, 2009·Journal of Biomechanics·Trevor J LujanMichael Bottlang
Feb 26, 2010·Journal of Orthopaedic Trauma·Trevor J LujanMichael Bottlang
Jul 3, 2010·The Journal of Bone and Joint Surgery. American Volume·Michael BottlangJ Lawrence Marsh
Feb 2, 2011·Journal of Orthopaedic Trauma·Christopher E HendersonJ L Marsh
May 27, 2011·Computer Methods in Biomechanics and Biomedical Engineering·D P ComiskeyJ O'Byrne
Apr 27, 2012·Journal of Orthopaedic Trauma·David J PallerBruce D Beynnon
May 27, 2014·Injury·Donald D AndersonDamien Lacroix
Feb 3, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yusuke HagiwaraDavid W Rowe

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Citations

Aug 25, 2016·Annals of Biomedical Engineering·Hwabok WeeGregory S Lewis
Feb 21, 2018·Journal of Orthopaedic Trauma·Christopher FinkemeierBrett D Crist
Jun 20, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Atsushi KogureEiji Itoi
Jun 20, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Miguel TrianaMark Lenz
May 22, 2018·Journal of Orthopaedic Trauma·Phillip M MitchellA Alex Jahangir
Oct 3, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Sami FinniläHannu T Aro
Jun 30, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Scott M TuckerGregory S Lewis
Oct 15, 2019·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Cédric P LaurentMarc Balligand
Nov 28, 2019·Journal of Orthopaedic Surgery and Research·Masahiro KiyonoToshifumi Ozaki
Mar 28, 2020·Current Osteoporosis Reports·Peter SchwarzenbergHannah L Dailey
Feb 2, 2021·Frontiers in Bioengineering and Biotechnology·Zhihua HanQiugen Wang
Feb 21, 2021·Medical Engineering & Physics·Hannah FerranteZ Shaghayegh Bagheri
May 22, 2021·Archives of Orthopaedic and Trauma Surgery·Jae Hoon JangYoon Young Choi
Jun 30, 2021·Current Osteoporosis Reports·Gregory S LewisPeter Varga
Aug 10, 2021·The Journal of the American Academy of Orthopaedic Surgeons·Gregory S LewisJ Spence Reid

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