Motivational changes that develop in a mouse model of inflammation-induced depression are independent of indoleamine 2,3 dioxygenase

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Elisabeth G VichayaRobert Dantzer

Abstract

Despite years of research, our understanding of the mechanisms by which inflammation induces depression is still limited. As clinical data points to a strong association between depression and motivational alterations, we sought to (1) characterize the motivational changes that are associated with inflammation in mice, and (2) determine if they depend on inflammation-induced activation of indoleamine 2,3 dioxygenase-1 (IDO1). Lipopolysaccharide (LPS)-treated or spared nerve injured (SNI) wild type (WT) and Ido1-/- mice underwent behavioral tests of antidepressant activity (e.g., forced swim test) and motivated behavior, including assessment of (1) reward expectancy using a food-related anticipatory activity task, (2) willingness to work for reward using a progressive ratio schedule of food reinforcement, (3) effort allocation using a concurrent choice task, and (4) ability to associate environmental cues with reward using conditioned place preference. LPS- and SNI-induced deficits in behavioral tests of antidepressant activity in WT but not Ido1-/- mice. Further, LPS decreased food related-anticipatory activity, reduced performance in the progressive ratio task, and shifted effort toward the preferred reward in the concurrent c...Continue Reading

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Citations

Nov 30, 2019·Alcoholism, Clinical and Experimental Research·A Leslie MorrowPatrizia Porcu
Jun 2, 2020·Journal of Neuroinflammation·Elisabeth G VichayaRobert Dantzer
Feb 26, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shijing WangSakina J Rizvi
Mar 7, 2021·The European Journal of Neuroscience·Sung Ching YeungChi Wai Cheung
Sep 28, 2020·Neuroscience and Biobehavioral Reviews·Ana Margarida CunhaHugo Leite-Almeida
May 30, 2021·Behavioural Pharmacology·Julie A MeadeM Imad Damaj

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GraphPad Prism
Noldus EthoVision XT
EthoVision XT
Statistical Package for Social Sciences

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