Motivational impairment predicts functional remission in first-episode psychosis: 3-Year follow-up of the randomized controlled trial on extended early intervention

The Australian and New Zealand Journal of Psychiatry
Wing Chung ChangEric Yu Hai Chen

Abstract

Functional remission represents an intermediate functional milestone toward recovery. Differential relationships of negative symptom sub-domains with functional remission in first-episode psychosis are understudied. We aimed to examine rate and predictors of functional remission in people with first-episode psychosis in the context of a 3-year follow-up of a randomized controlled trial comparing 1-year extension of early intervention (i.e. 3-year early intervention) with step-down psychiatric care (i.e. 2-year early intervention). A total of 160 participants were recruited upon completion of a 2-year specialized early intervention program for first-episode psychosis in Hong Kong and underwent a 1-year randomized controlled trial comparing 1-year extended early intervention with step-down care. Participants were followed up and reassessed 3 years after inclusion to the trial (i.e. 3-year follow-up). Functional remission was operationalized as simultaneous fulfillment of attaining adequate functioning (measured by Social and Occupational Functioning Scale and Role Functioning Scale) at 3-year follow-up and sustained employment in the last 6 months of 3-year study period. Negative symptom measure was delineated into amotivation (i...Continue Reading

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Citations

Jul 9, 2020·Journal of Clinical Psychopharmacology·Martina Rojnic KuzmanMaja Zivkovic
Nov 3, 2020·The Cochrane Database of Systematic Reviews·Stephen PuntisRachael Harrison
Nov 3, 2020·The Cochrane Database of Systematic Reviews·Stephen PuntisRachael Harrison
Jan 19, 2022·Social Psychiatry and Psychiatric Epidemiology·Ashok MallaHoward C Margolese

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