Motivations to participate in a Phase I/II HIV vaccine trial: A descriptive study from Dar es Salaam, Tanzania

BMC Public Health
Edith A M TarimoAsli Kulane

Abstract

The search for an efficacious HIV vaccine is a global priority. To date only one HIV vaccine trial (RV144) has shown modest efficacy in a phase III trial. With existing different HIV-1 subtypes and frequent mutations, multiple trials are needed from different geographical sites particularly in sub-Saharan Africa where most HIV infections occur. Thus, motivations to participate in HIV vaccine trials among Tanzanians need to be assessed. This paper describes the motives of Police Officers who showed great interest to volunteer in HIVIS-03 in Dar es Salaam, Tanzania. A descriptive cross-sectional study was conducted among Police Officers who showed interest to participate in the HIVIS-03, a phase I/II HIV vaccine trial in Dar es Salaam. Prior to detailed training sessions about HIV vaccine trials, the potential participants narrated their individual motives to participate in the trial on a piece of paper. Descriptive analysis using content approach and frequency distributions were performed. Of the 265 respondents, 242 (91.3%) provided their socio-demographic characteristics as well as reasons that would make them take part in the proposed trial. Majority, (39.7%), cited altruism as the main motive. Women were more likely to volun...Continue Reading

References

Sep 2, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·S SenguptaW B Ware
Jan 6, 2001·Sexually Transmitted Infections·R A JenkinsS Nitayaphan
Feb 15, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·R P StraussK M MacQueen
Jul 27, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·J W McGrathE Mugisha
Dec 11, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jacqueline M O'ConnellRobert Remis
May 29, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Noah KiwanukaRonald H Gray
Jan 22, 2005·Vaccine·Seema SahayRamesh Paranjape
May 19, 2005·International Journal of STD & AIDS·Paul Van de VenSusan Kippax
Jun 28, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Grant ColfaxBrad Bartholow
Jul 12, 2005·AIDS Education and Prevention : Official Publication of the International Society for AIDS Education·Ellen T RudyDanielle S Seiden
Jan 6, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Peter A NewmanSvetlana Popova
Feb 12, 2009·Tropical Medicine & International Health : TM & IH·Eugene RuzagiraAnatoli Kamali
Feb 26, 2009·AIDS Research and Human Retroviruses·Mohanarani SuhadevP Venkatesan
Oct 22, 2009·The New England Journal of Medicine·Supachai Rerks-NgarmUNKNOWN MOPH-TAVEG Investigators

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