MotomiRs: miRNAs in Motor Neuron Function and Disease

Frontiers in Molecular Neuroscience
Zachary C E HawleyMichael J Strong

Abstract

MiRNAs are key regulators of the mammalian transcriptome that have been increasingly linked to degenerative diseases of the motor neurons. Although many of the miRNAs currently incriminated as participants in the pathogenesis of these diseases are also important to the normal development and function of motor neurons, at present there is no knowledge of the complete miRNA profile of motor neurons. In this review, we examine the current understanding with respect to miRNAs that are specifically required for motor neuron development, function and viability, and provide evidence that these should be considered as a functional network of miRNAs which we have collectively termed MotomiRs. We will also summarize those MotomiRs currently known to be associated with both amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), and discuss their potential use as biomarkers.

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Citations

Oct 3, 2018·Expert Review of Neurotherapeutics·Arens Taga, Nicholas J Maragakis
Jun 30, 2019·International Journal of Molecular Sciences·Takashi HosakaShin Kwak
Jun 12, 2019·International Journal of Molecular Sciences·Serena MaggioMichele Guescini
Oct 4, 2017·Molecular Brain·Zachary C E HawleyMichael J Strong
Jul 22, 2018·Molecular Brain·Danae Campos-MeloMichael J Strong
Feb 7, 2019·Frontiers in Genetics·Zoe Butti, Shunmoogum A Patten
Jan 26, 2021·Therapeutic Advances in Neurological Disorders·Tai-Heng Chen
Feb 23, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Valeria ValsecchiLucio Annunziato
Jul 3, 2021·International Journal of Molecular Sciences·Ana Rita VazDora Brites

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Methods Mentioned

BETA
acetylation
immunoprecipitation
Transgenic
Nucleotide Exchange
SMA
antisense oligonucleotides

Software Mentioned

MotomiRs

Related Concepts

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