Motoneuron injury and repair: New perspectives on gonadal steroids as neurotherapeutics.

Journal of Molecular Neuroscience : MN
Julie TetzlaffKathryn J Jones

Abstract

In this review, we will summarize recent work from our laboratory on the role of gonadal steroids as neuroprotective agents in motoneuron viability following cell stress. Three motoneuron models will be discussed: developing axotomized hamster facial motoneurons (FMNs); adult axotomized mouse FMNs; and immortalized, cultured mouse spinal motoneurons subjected to heat shock. New work on two relevant motoneuron proteins, the survival of motor neuron protein, and neuritin or candidate plasticity-related gene 15, indicates differential steroid regulation of these two proteins after axotomy. The concept of gonadal steroids as cellular stress correction factors and the implications of this for acute neurological injury situations will be presented as well.

Citations

Jan 17, 2013·Cellular and Molecular Neurobiology·Andrea Cardona-RossinyolGabriel Olmos
Oct 1, 2009·Physiological Reviews·Sven Loebrich, Elly Nedivi
Jan 12, 2017·The Annals of Otology, Rhinology, and Laryngology·Steven J CharousEileen M Foecking
Jan 22, 2008·The Journal of Urology·Holly E RichterUNKNOWN Urinary Incontinence Treatment Network
Mar 6, 2007·Journal of Neuroscience Research·Graziella CappellettiAngelo Poletti
Jan 29, 2008·Hormones and Behavior·Christian J PikeEmily R Rosario
Apr 28, 2009·Frontiers in Neuroendocrinology·Keith N FargoDale R Sengelaub

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