Motor activity and gene expression in rats with neonatal 6-hydroxydopamine lesions

Journal of Neurochemistry
Yoshinori MasuoEtsuo Niki

Abstract

A rat model of a hyperkinetic disorder was used to investigate the mechanisms underlying motor hyperactivity. Rats received an intracisternal injection of 6-hydroxydopamine on post-natal day 5. At 4 weeks of age, the animals showed significant motor hyperactivity during the dark phase, which was attenuated by methamphetamine injection. Gene expression profiling was carried out in the striatum and midbrain using a DNA macroarray. In the striatum at 4 weeks, there was increased gene expression of the NMDA receptor 1 and tachykinins, and decreased expression of a GABA transporter. At 8 weeks, expression of the NMDA receptor 1 in the striatum was attenuated, with enhanced expression of the glial glutamate/aspartate transporter. In the midbrain, a number of genes, including the GABA transporter gene, showed decreased expression at 4 weeks. At 8 weeks, gene expression was augmented for the dopamine transporter, D4 receptor, and several genes encoding peptides, such as tachykinins and their receptors. These results suggest that in the striatum the neurotransmitters glutamate, GABA and tachykinin may play crucial roles in motor hyperactivity during the juvenile period. Several classes of neurotransmitters, including dopamine and peptid...Continue Reading

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Citations

Jul 28, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Yoshinori Masuo, Masami Ishido
Feb 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gregorio L GaliñanesM Gustavo Murer
Jul 6, 2007·The European Journal of Neuroscience·Yoshinori MasuoEtsuo Niki
Dec 3, 2015·World Journal of Biological Chemistry·Yuka KobayashiYoshinori Masuo
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yoshinori MasuoKazuo Koike

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