Mar 5, 1991

Motor activity and neurotransmitter release in the gastric fundus of streptozotocin-diabetic rats

European Journal of Pharmacology
A BelaiGeoffrey Burnstock


As deficiencies of the cholinergic and non-adrenergic non-cholinergic innervation of the gastrointestinal tract have been described in diabetic rats, we studied the simultaneous release of, and muscular response to, acetylcholine, vasoactive intestinal polypeptide and adenosine-5'-triphosphate in isolated preparations of gastric fundus from control and 8-week streptozotocin-treated diabetic rats. Muscular responses were measured in longitudinal muscle strips prepared from one half of the gastric fundus and release was studied in the other half. The contractile response to acetylcholine and electrical field stimulation was not different in control and diabetic rats. In the presence of atropine, and when tone was increased with prostaglandin F2 alpha, electrical field stimulation, vasoactive intestinal polypeptide and adenosine-5'-triphosphate induced relaxation with a similar response in control and diabetic rats. The basal release of acetylcholine, vasoactive intestinal polypeptide and adenosine-5'-triphosphate was not significantly different in control and diabetic rats. Electrical field stimulation significantly increased the release of the three substances and this increase was tetrodotoxin-sensitive. While the stimulation-i...Continue Reading

Mentioned in this Paper

Molecular Motor Activity
Prostaglandin F2 Alpha Measurement
Neurotransmitter Secretion
Entire Gastrointestinal Tract
Muscle Innervation, Function
August Rats
Acute Cholinergic Dysautonomia
Synaptic Transmission

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