Motor activity changes and conditioned taste aversions induced by administration of scopolamine in rats: role of the area postrema

Pharmacology, Biochemistry, and Behavior
Klaus-Peter OssenkoppR L Ladowsky

Abstract

Three experiments examined the effects of centrally and peripherally acting scopolamine (scopolamine hydrochloride-SHC) or only peripherally acting scopolamine (scopolamine methyl nitrate-SMN), on motor activity levels and the ability of these agents to induce taste aversions. In Experiment 1 rats were injected with isotonic saline, 1 mg/kg SHC, or 1 mg/kg SMN. SHC produced significant increases in stabilimeter activity (p less than 0.025) and in rearing response frequency (p less than 0.01), whereas SMN resulted in significantly less activity (p less than 0.025). Both agents induced strong conditioned taste aversions to saccharin (p less than 0.01). Experiment 2 examined the role of the area postrema in mediating these drug induced behavioral changes. Sham lesioned and area postrema lesioned rats were given saline, SHC or SMN (1 mg/kg for both drugs) and examined for changes in activity, rearing response frequency and induction of taste aversions to saccharin. SHC again produced significant increases in activity (p less than 0.01), whereas SMN produced decrements in activity (p less than 0.05). However, the brain lesion did not consistently alter the effects of these drugs on activity but it did reduce the amount of the decrem...Continue Reading

References

May 1, 1975·Pharmacology, Biochemistry, and Behavior·O L WolthuisR A Vanwersch
Jan 1, 1985·Annals of the New York Academy of Sciences·J GarciaD A Deems
Feb 1, 1985·Brain Research Bulletin·N W Pedigo, K R Brizzee
Nov 1, 1972·European Journal of Pharmacology·S M AquiloniusB Winbladh
Mar 1, 1973·Journal of Comparative and Physiological Psychology·B D BergerL Stein
Oct 1, 1972·Journal of Comparative and Physiological Psychology·B D Berger
Jun 1, 1970·British Journal of Pharmacology·R M AbelR N Staroscik
Apr 1, 1983·Physiology & Behavior·D H Thor, W R Holloway
Nov 17, 1980·Brain Research·S RitterK W Kelley
Sep 6, 1974·Science·J GarciaK W Rusiniak
May 1, 1951·Proceedings of the Society for Experimental Biology and Medicine·H L BORISON, K R BRIZZEE

❮ Previous
Next ❯

Citations

Jul 1, 1990·Pharmacology, Biochemistry, and Behavior·K P Ossenkopp, L Giugno
Mar 1, 1990·Pharmacology, Biochemistry, and Behavior·M GalloA Puerto
Feb 1, 1991·Pharmacology, Biochemistry, and Behavior·M S HooksJ B Justice
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·K P Ossenkopp, L A Eckel
Mar 1, 1991·Behavioral and Neural Biology·M ArnedoA Puerto
Jan 1, 1993·Behavioral and Neural Biology·M ArnedoA Puerto
Jan 31, 1994·Behavioural Brain Research·E Bielavska, J Bures
Sep 19, 2003·Pharmacology, Biochemistry, and Behavior·Shelley K Cross-MellorKlaus-Peter Ossenkopp
Oct 30, 2001·Behavioural Brain Research·H WelzlH P Lipp
Oct 9, 2001·Brain Research. Molecular Brain Research·C M Spencer, T A Houpt
May 9, 2002·Behavioral Neuroscience·Khalid Touzani, Anthony Sclafani
May 20, 2003·The European Journal of Neuroscience·Ranier GutiérrezFederico Bermúdez-Rattoni
Aug 1, 1988·The Journal of Pharmacy and Pharmacology·N M BarnesF D Tattersall
Jun 24, 2017·American Journal of Alzheimer's Disease and Other Dementias·Ioana-Miruna Balmus, Alin Ciobica

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.