Motor activity (exploration) and formation of home bases in mice (C57BL/6) influenced by visual and tactile cues: modification of movement distribution, distance, location, and speed

Physiology & Behavior
Benjamin J ClarkIan Q Whishaw

Abstract

The motor activity of mice in tests of "exploration" is organized. Mice establish home bases, operationally defined as places where they spend long periods of time, near physical objects and nesting material from which they make excursions. This organization raises the question of the extent to which mouse motoric activity is modulated by innate predispositions versus environmental influences. Here the influence of contextual cues (visual and tactile) on the motor activity of C57BL/6 mice was examined: (1) on an open field that had no walls, a partial wall, or a complete wall, (2) in the presence of distinct visual cues, room cues, or in the absence of visual cues (infrared light), and (3) in the presence of configurations of visual and tactile cues. Mice were generally less active in the presence of salient cues and formed home bases near those cues. In addition, movement speed, path distribution, and the number and length of stops were modulated by contextual cues. With repeated tests, mice favored tactile cues over visual cues as their home base locations. Although responses to cues were robust over test days, conditioning to context was generally weak. That the exploratory behavior of mice is affected by experience and cont...Continue Reading

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Citations

Feb 24, 2007·Animal Cognition·Osnat Yaski, David Eilam
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yoav BenjaminiIlan Golani
Jan 22, 2010·PLoS Computational Biology·Anna DvorkinIlan Golani
Dec 10, 2013·Hormones and Behavior·Jamshid FarajiGerlinde A S Metz
Sep 30, 2014·Neuroscience and Biobehavioral Reviews·David Eilam
Aug 3, 2010·Behavioural Processes·Adam StewartAllan V Kalueff
Jan 30, 2010·Neurobiology of Learning and Memory·Stephane ValerioJeffrey S Taube
Jan 29, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Allan V KalueffKenneth Sufka
Jan 23, 2015·Frontiers in Behavioral Neuroscience·Anne NosjeanSylvie Granon
Jun 25, 2014·Animal Cognition·Omri WeissDavid Eilam
Nov 9, 2007·Behavioural Brain Research·Osnat Yaski, David Eilam
Jul 25, 2020·ELife·Angie M MichaielCristopher M Niell
Jul 15, 2017·Scientific Reports·Jamshid FarajiGerlinde A S Metz
Sep 23, 2020·Animal Cognition·Selim Jedidi-AyoubRoddy M Grieves
Dec 30, 2020·Neuroscience and Biobehavioral Reviews·Alex DorfmanDavid Eilam
Feb 9, 2021·Experimental Brain Research·Mark T BanovetzDouglas G Wallace
Oct 3, 2018·Learning and Motivation·Shannon M ThompsonBenjamin J Clark
Jun 6, 2021·Behavioural Processes·Jenna R Osterlund OltmannsDouglas G Wallace
Aug 16, 2011·Behavioural Brain Research·Osnat YaskiDavid Eilam

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