Motor and electrical signs of epileptiform activity induced by penicillin in the spinal cords of decapitate cats

Electroencephalography and Clinical Neurophysiology
E W Lothman, G G Somjen

Abstract

Convulsive activity was induced in functionally decapitate cat preparations by topical and by systemic administration of toxic amounts of penicillin. The paroxysmal movement patterns and the electrographic signs of spinal seizure activity recorded from spinal ventral and dorsal roots and from the dorsal surface of the spinal cord are described. Paroxysms of interictal myoclonic twitching as well as tonic and clonic ictal seizures reminiscent of epileptiform convulsions of intact animals were seen in the absence of descending influences from the brain. Tonic seizures consisted of flexion--extension sequences; co-contraction of antagonistic muscles was the rule. Clonic activity consisted of rhythmic discharges at 4--6/sec, In dorsal roots, electrotonically conducted paroxysmal negative potential shifts as well as antidromically conducted trains of impulses were recorded. Ictal paroxysmal waves of the cord dorsum potential consisted of either biphasic positive--negative sequences or of purely negative waves. Diphenylhydantoin effectively controlled spinal seizures in the absence of a functioning cerebellum. Diphenylthiohydantoin changed the pattern of seizures, suppressing all ictal activity and greatly enhancing the amplitude and...Continue Reading

References

Sep 1, 1976·Electroencephalography and Clinical Neurophysiology·E W Lothman, G G Somjen
Oct 27, 1972·Brain Research·R A Davidoff
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Citations

Feb 1, 1981·Biulleten' eksperimental'noĭ biologii i meditsiny·M B RekhtmanN V Darinskiĭ
Sep 1, 1976·Electroencephalography and Clinical Neurophysiology·E W Lothman, G G Somjen
Sep 15, 2005·Journal of Neurosurgery·R Shane TubbsW Jerry Oakes
Nov 3, 2010·Journal of Pediatric Neurosciences·Zohreh HabibiMostafa El Khashab
Nov 23, 2005·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·R Shane TubbsW Jerry Oakes
Jul 1, 1977·Experimental Neurology·J DavenportW E Crill
Feb 23, 2008·Seizure : the Journal of the British Epilepsy Association·Seyed M MirsattariNagalingam Rajakumar
Jan 1, 1987·Acta Anaesthesiologica Scandinavica. Supplementum·R Payne

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